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Table 4 Changes in illness severity and outcomes over time in infants <1000 g

From: Increasing illness severity in very low birth weight infants over a 9-year period

Infants <1000 g

Cohort 1 1993–1996, n = 165

Cohort 2 1996–1999, n = 199

Cohort 3 1999–2002, n = 246

T4 (μg/dl)

5.4 ± 2.9

5.3 ± 3.1

4.7 ± 3.3 *

SNAP

NA

15.3 ± 7.4

18.3 ± 8.9 †

Death

30%

27%

33%

Severe IVH

16%

14%

23% †

Death/Severe IVH

35%

36%

46% * †

  1. *p < .05, Cohort 1v 3
  2. ‡p < .05, Cohort 1 vs 2
  3. †p < .05, Cohort 2 vs 3