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Table 3 Changes in illness severity and outcomes over time

From: Increasing illness severity in very low birth weight infants over a 9-year period

  Cohort 1 1993–1996, n = 393 Cohort 2 1996–1999, n = 485 Cohort 3 1999–2002, N = 536
T4 (μg/dl) 7.6 ± 3.8 ‡ 7.0 ± 3.4 6.5 ± 3.9 * †
SNAP NA 11.2 ± 5.8 13.4 ± 7.6 †
Death 14% 13% 16%
Day of death (median, interquartile range) 7 (2–21) 10.5 (2–22) 3 (2–10) * †
Severe IVH 9% 9% 14% * †
Death and/or Severe IVH 18% 19% 26% * †
  1. *p < .05, Cohort 1vs 3
  2. ‡p < .05, Cohort 1 vs 2
  3. †p < .05, Cohort 2 vs 3