From: Increasing illness severity in very low birth weight infants over a 9-year period
Cohort 1 1993–1996 n = 393 | Cohort 2 1996–1999 n = 485 | Cohort 3 1999–2002 n = 536 | |
---|---|---|---|
Birthweight (g) | 1052 ± 297 | 1057 ± 277 | 1028 ± 284 |
Gestational Age (weeks) | 28.3 ± 3.0 | 28.4 ± 2.9 | 27.8 ± 2.9 * † |
Maternal age (years) | 26.5 ± 5.9 | 26.6 ± 6.3 | 26.7 ± 6.7 |
Inborn | 91% | 88% | 87% |
Apgar score at 5 minutes (median, interquartile range) | 8 (6–9) | 8 (7–9) | 8 (7–9) |
Apgar score at 5 minutes <5 | 13% | 8% | 10% |
Cesarean delivery | 55% | 57% | 62% * |
Antenatal steroids | 48% ‡ | 66% | 65% * |
Antenatal antibiotics | 34% ‡ | 50% | 51% * |
Preeclampsia | 14% ‡ | 20% | 24% * |
HELLP syndrome | 5% | 4% | 3% |
Oligohydramnios | 14% | 11% | 13% |
Clinical chorioamnionitis | 9% | 7% | 8% |
Maternal fever | 4% | 2% | 4% |
Prolonged rupture of membranes | 22% | 22% | 21% |
Illicit maternal drug use | 3% | 2% | 3% |
Maternal diabetes | 5% | 3.5% | 5% |
Multiple gestation births | 24% | 24% | 28% |
Infertility | 10% | 7% | 10% |
Mechanical ventilation | 78% | 79% | 83% |
Rescue high frequency ventilation | 13% | 15% | 22% *† |
Exogenous surfactant replacement | 63% | 65% | 75% *† |
Postnatal dopamine | 24% ‡ | 31% | 35% * |
Postnatal dexamethasone | 19% ‡ | 25% | 16% † |