Table 3 Diagnostic accuracy of serum PCT for the diagnosis of neonatal sepsis of nosocomial origin
Data | Onset of symptoms | 12–24 h | 36–48 h |
|---|---|---|---|
Cutoff value, ng/mL | 0.59 | 1.34 | 0.69 |
Sensitivity, % (95% CI) | 81.4 (69.6–89.3) | 73.7 (61.0–83.4) | 86.5 (74.7–93.3) |
Specificity, % (95% CI) | 80.6 (65.0–90.2) | 80.6 (65.0–90.2) | 72.7 (55.8–84.9) |
Positive predictive value, % (95% CI) | 87.3 (76.0–93.7) | 85.7 (73.3–92.9) | 83.3 (71.3–91.0) |
Negative predictive value, % (95% CI) | 72.5 (57.2–83.9) | 65.9 (51.1–78.1) | 77.4 (60.2–88.6) |
Youden's index | 0.62 | 0.54 | 0.59 |
Likelihood ratio of a positive result (95% CI) | 4.18 (2.13–8.23) | 3.79 (1.91–7.50) | 3.17 (1.80–5.60) |
Likelihood ratio of a negative result (95% CI) | 0.23 (0.13–0.40) | 0.33 (0.21–0.52) | 0.19 (0.09–0.38) |