Association between congenital toxoplasmosis and parent-reported developmental outcomes, concerns, and impairments, in 3 year old children

Table 4 Factors associated with parent-reported impairment at 3 years adjusted for centre and congenital infection status (Total N = 705)

	Odds ratio for adverse outcome (95% confidence interval)
EXPOSURES	Any visual impairment³	Hearing loss⁴	Neurological/mobility impairment⁵
Before birth
1) Congenital toxoplasmosis	2.22 (1.10, 4.49)	0.61 (0.26, 1.46)	1.88 (0.32, 11.04)
2) Maternal Age ¹	0.99 (0.92, 1.07)	0.91 (0.92, 1.07)	1.15 (0.94, 1.42)
3) Parity ¹	1.08 (0.82, 1.43)	0.77 (0.84, 0.99)	1.63 (1.01, 2.63)
4) Maternal Education ¹	1.13 (0.77, 1.65)	0.96 (0.67, 1.37)	0.70 (0.27, 1.79)
5) Mother born outside country ² (no = reference)	0.35 (0.08, 1.53)	0.54 (0.16, 1.87)	Not estimable
6) Child's gender (male = reference)	1.76 (0.88, 3.51)	1.27 (0.64, 2.50)	0.78 (0.15, 3.98)
7) Duration of prenatal treatment (wks)	0.95 (0.92, 0.99)	1.01 (0.97, 1.04)	0.96 (0.87, 1.06)
After birth
8) Child's age at Questionnaire ¹ (month)	1.02 (0.93, 1.11)	0.90 (0.79, 1.03)	1.05 (0.86, 1.29)

¹Odds ratio for effect of exposure on outcome in all subjects per additional unit increase in exposure variable, adjusted for centre ²Odds ratio for effect of exposure on outcome, adjusted for centre ³Defined as any visual impairment, including wearing glasses ⁴Defined as any intermittent or permanent hearing loss ⁵Defined as seizures requiring treatment, cerebral palsy, and/or impaired

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