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Table 2 HPRT mutational spectra in newborns with and without exposure to tobacco smoke metabolites in utero

From: Qualitatively and quantitatively similar effects of active and passive maternal tobacco smoke exposure on in utero mutagenesis at the HPRT locus

a) distribution of mutant clones
maternal exposure study total independent mutants small mutations (%) deletions, rearrangements (%) VDJ recombinant deletions (%) P1
unexposed Finette et al [23] 30 10 (33) 14 (47) 6 (20)  
mixed McGinniss et al [11] 41 7 (17) 14 (34) 20 (49) 0.039
mixed Manchester et al [21] 38 13 (34) 16 (42) 9 (24) 0.91
passively exposed Finette et al [23] 35 17 (49) 6 (17) 12 (34) 0.036
b) mutation frequencies for three classes of mutants based on individual studies
maternal exposure study overall mean M f ± SD (× 10-6) small mutations M f (× 10-6) deletions, rearrangements M f (× 10-6) VDJ recombinant deletions M f (× 10-6) P2
unexposed Finette et al [22,23] 0.72 ± 0.53 0.24 0.34 0.14  
mixed McGinniss et al [11] 0.64 ± 0.40 0.11 0.22 0.31 0.003
mixed Manchester et al [21] 1.32 ± 1.093 0.45 0.56 0.31 < 0.001
passively exposed Finette et al [22,23] 1.18 ± 1.284 0.57 0.20 0.40 0.002
c) mutation frequencies for three classes of mutants based on pooled data 5
unexposed Finette et al [22,23] 0.73 ± 0.51 0.24 0.34 0.15  
mixed McGinniss et al [11] 0.99 ± 0.95 0.17 0.34 0.48 0.008
mixed Manchester et al [21] 0.99 ± 0.953 0.34 0.42 0.24 0.037
passively exposed Finette et al [22,23] 1.38 ± 1.364 0.67 0.24 0.47 < 0.001
  1. 1χ2
  2. 2 t tests on ln transformed data
  3. 3excluding outlier with HPRT M f of 14.7 × 10-6
  4. 4excluding outlier with HPRT M f of 45.3 × 10-6
  5. 5for the purposes of this analysis the data of McGinniss et al [11] was pooled with that of Manchester et al [21] and Finette et al [22,23] to yield a single M f .