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Table 2 HPRT mutational spectra in newborns with and without exposure to tobacco smoke metabolites in utero

From: Qualitatively and quantitatively similar effects of active and passive maternal tobacco smoke exposure on in utero mutagenesis at the HPRT locus

a) distribution of mutant clones

maternal exposure

study

total independent mutants

small mutations (%)

deletions, rearrangements (%)

VDJ recombinant deletions (%)

P1

unexposed

Finette et al [23]

30

10 (33)

14 (47)

6 (20)

 

mixed

McGinniss et al [11]

41

7 (17)

14 (34)

20 (49)

0.039

mixed

Manchester et al [21]

38

13 (34)

16 (42)

9 (24)

0.91

passively exposed

Finette et al [23]

35

17 (49)

6 (17)

12 (34)

0.036

b) mutation frequencies for three classes of mutants based on individual studies

maternal exposure

study

overall mean M f ± SD (× 10-6)

small mutations M f (× 10-6)

deletions, rearrangements M f (× 10-6)

VDJ recombinant deletions M f (× 10-6)

P2

unexposed

Finette et al [22,23]

0.72 ± 0.53

0.24

0.34

0.14

 

mixed

McGinniss et al [11]

0.64 ± 0.40

0.11

0.22

0.31

0.003

mixed

Manchester et al [21]

1.32 ± 1.093

0.45

0.56

0.31

< 0.001

passively exposed

Finette et al [22,23]

1.18 ± 1.284

0.57

0.20

0.40

0.002

c) mutation frequencies for three classes of mutants based on pooled data 5

unexposed

Finette et al [22,23]

0.73 ± 0.51

0.24

0.34

0.15

 

mixed

McGinniss et al [11]

0.99 ± 0.95

0.17

0.34

0.48

0.008

mixed

Manchester et al [21]

0.99 ± 0.953

0.34

0.42

0.24

0.037

passively exposed

Finette et al [22,23]

1.38 ± 1.364

0.67

0.24

0.47

< 0.001

  1. 1χ2
  2. 2 t tests on ln transformed data
  3. 3excluding outlier with HPRT M f of 14.7 × 10-6
  4. 4excluding outlier with HPRT M f of 45.3 × 10-6
  5. 5for the purposes of this analysis the data of McGinniss et al [11] was pooled with that of Manchester et al [21] and Finette et al [22,23] to yield a single M f .