a) distribution of mutant clones | ||||||
maternal exposure | study | total independent mutants | small mutations (%) | deletions, rearrangements (%) | VDJ recombinant deletions (%) | P1 |
unexposed | Finette et al [23] | 30 | 10 (33) | 14 (47) | 6 (20) | Â |
mixed | McGinniss et al [11] | 41 | 7 (17) | 14 (34) | 20 (49) | 0.039 |
mixed | Manchester et al [21] | 38 | 13 (34) | 16 (42) | 9 (24) | 0.91 |
passively exposed | Finette et al [23] | 35 | 17 (49) | 6 (17) | 12 (34) | 0.036 |
b) mutation frequencies for three classes of mutants based on individual studies | ||||||
maternal exposure | study | overall mean M f ± SD (× 10-6) | small mutations M f (× 10-6) | deletions, rearrangements M f (× 10-6) | VDJ recombinant deletions M f (× 10-6) | P2 |
unexposed | Finette et al [22,23] | 0.72 ± 0.53 | 0.24 | 0.34 | 0.14 |  |
mixed | McGinniss et al [11] | 0.64 ± 0.40 | 0.11 | 0.22 | 0.31 | 0.003 |
mixed | Manchester et al [21] | 1.32 ± 1.093 | 0.45 | 0.56 | 0.31 | < 0.001 |
passively exposed | Finette et al [22,23] | 1.18 ± 1.284 | 0.57 | 0.20 | 0.40 | 0.002 |
c) mutation frequencies for three classes of mutants based on pooled data 5 | ||||||
unexposed | Finette et al [22,23] | 0.73 ± 0.51 | 0.24 | 0.34 | 0.15 |  |
mixed | McGinniss et al [11] | 0.99 ± 0.95 | 0.17 | 0.34 | 0.48 | 0.008 |
mixed | Manchester et al [21] | 0.99 ± 0.953 | 0.34 | 0.42 | 0.24 | 0.037 |
passively exposed | Finette et al [22,23] | 1.38 ± 1.364 | 0.67 | 0.24 | 0.47 | < 0.001 |