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Table 1 HPRT M f in newborns with and without exposure to tobacco smoke metabolites in utero

From: Qualitatively and quantitatively similar effects of active and passive maternal tobacco smoke exposure on in utero mutagenesis at the HPRT locus

  

HPRT M f (× 10-6)

  

maternal exposure

N

mean ± SD

median

range

P1,2

P2,3

a) data from Manchester et al [21]

unexposed

18

0.76 ± 0.50

0.61

0.14 – 1.9

  

passive only

20

1.60 ± 1.43

1.35

0.30 – 5.3

0.021

 

quit during pregnancy4

4

1.85 ± 1.16

1.60

0.35 – 3.2

0.004

 

smoked throughout

27

1.36 ± 0.99

0.98

0.28 – 3.5

0.019

0.012

b) data from Finette et al [22,23]

unexposed

26

0.72 ± 0.53

0.52

0.05 – 1.9

  

passive only5

22

1.18 ± 1.28

0.67

0.10 – 5.1

0.14

 

quit during pregnancy

8

0.79 ± 0.46

0.69

0.18 – 1.8

0.51

 

smoked throughout

12

0.71 ± 0.51

0.56

0.14 – 1.8

0.73

0.47

c) pooled data

unexposed

44

0.73 ± 0.51

0.60

0.05 – 1.9

  

passive only5

42

1.38 ± 1.36

0.87

0.10 – 5.3

0.006

 

quit during pregnancy4

12

1.27 ± 0.93

0.91

0.18 – 3.2

0.014

 

smoked throughout

39

1.16 ± 0.91

0.87

0.14 – 3.5

0.007

0.007

  1. 1specific exposed group vs. unexposed HPRT M f from single factor ANOVA on ln transformed data
  2. 2since these four tests were performed simultaneously, to preserve an overall α of 0.05, the threshold for significance of each individual test should be set at P = 0.0125, or, if exposure is only tested for an induction of mutation, P = 0.025
  3. 3overall single factor ANOVA on ln transformed data
  4. 4excluding outlier with HPRT M f of 14.7 × 10-6
  5. 5excluding outlier with HPRT M f of 45.3 × 10-6
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BMC Pediatrics

ISSN: 1471-2431

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