| | |
HPRT M
f
(× 10-6)
| | |
|
maternal exposure
|
N
|
mean ± SD
|
median
|
range
|
P1,2
|
P2,3
|
|
a) data from Manchester et al [21]
|
|
unexposed
|
18
|
0.76 ± 0.50
|
0.61
|
0.14 – 1.9
| | |
|
passive only
|
20
|
1.60 ± 1.43
|
1.35
|
0.30 – 5.3
|
0.021
| |
|
quit during pregnancy4
|
4
|
1.85 ± 1.16
|
1.60
|
0.35 – 3.2
|
0.004
| |
|
smoked throughout
|
27
|
1.36 ± 0.99
|
0.98
|
0.28 – 3.5
|
0.019
|
0.012
|
|
b) data from Finette et al [22,23]
|
|
unexposed
|
26
|
0.72 ± 0.53
|
0.52
|
0.05 – 1.9
| | |
|
passive only5
|
22
|
1.18 ± 1.28
|
0.67
|
0.10 – 5.1
|
0.14
| |
|
quit during pregnancy
|
8
|
0.79 ± 0.46
|
0.69
|
0.18 – 1.8
|
0.51
| |
|
smoked throughout
|
12
|
0.71 ± 0.51
|
0.56
|
0.14 – 1.8
|
0.73
|
0.47
|
|
c) pooled data
|
|
unexposed
|
44
|
0.73 ± 0.51
|
0.60
|
0.05 – 1.9
| | |
|
passive only5
|
42
|
1.38 ± 1.36
|
0.87
|
0.10 – 5.3
|
0.006
| |
|
quit during pregnancy4
|
12
|
1.27 ± 0.93
|
0.91
|
0.18 – 3.2
|
0.014
| |
|
smoked throughout
|
39
|
1.16 ± 0.91
|
0.87
|
0.14 – 3.5
|
0.007
|
0.007
|
-
1specific exposed group vs. unexposed HPRT M
f
from single factor ANOVA on ln transformed data
-
2since these four tests were performed simultaneously, to preserve an overall α of 0.05, the threshold for significance of each individual test should be set at P = 0.0125, or, if exposure is only tested for an induction of mutation, P = 0.025
-
3overall single factor ANOVA on ln transformed data
-
4excluding outlier with HPRT M
f
of 14.7 × 10-6
-
5excluding outlier with HPRT M
f
of 45.3 × 10-6
