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Table 1 HPRT M f in newborns with and without exposure to tobacco smoke metabolites in utero

From: Qualitatively and quantitatively similar effects of active and passive maternal tobacco smoke exposure on in utero mutagenesis at the HPRT locus

   HPRT M f (× 10-6)   
maternal exposure N mean ± SD median range P1,2 P2,3
a) data from Manchester et al [21]
unexposed 18 0.76 ± 0.50 0.61 0.14 – 1.9   
passive only 20 1.60 ± 1.43 1.35 0.30 – 5.3 0.021  
quit during pregnancy4 4 1.85 ± 1.16 1.60 0.35 – 3.2 0.004  
smoked throughout 27 1.36 ± 0.99 0.98 0.28 – 3.5 0.019 0.012
b) data from Finette et al [22,23]
unexposed 26 0.72 ± 0.53 0.52 0.05 – 1.9   
passive only5 22 1.18 ± 1.28 0.67 0.10 – 5.1 0.14  
quit during pregnancy 8 0.79 ± 0.46 0.69 0.18 – 1.8 0.51  
smoked throughout 12 0.71 ± 0.51 0.56 0.14 – 1.8 0.73 0.47
c) pooled data
unexposed 44 0.73 ± 0.51 0.60 0.05 – 1.9   
passive only5 42 1.38 ± 1.36 0.87 0.10 – 5.3 0.006  
quit during pregnancy4 12 1.27 ± 0.93 0.91 0.18 – 3.2 0.014  
smoked throughout 39 1.16 ± 0.91 0.87 0.14 – 3.5 0.007 0.007
  1. 1specific exposed group vs. unexposed HPRT M f from single factor ANOVA on ln transformed data
  2. 2since these four tests were performed simultaneously, to preserve an overall α of 0.05, the threshold for significance of each individual test should be set at P = 0.0125, or, if exposure is only tested for an induction of mutation, P = 0.025
  3. 3overall single factor ANOVA on ln transformed data
  4. 4excluding outlier with HPRT M f of 14.7 × 10-6
  5. 5excluding outlier with HPRT M f of 45.3 × 10-6