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Table 4 Changes in respiratory indices at PCW and at PC20-FEV1. The results are expressed as mean ± SD. (n = 35/36, as one child did not respond to MCH and his spirometry did not change throughout the test).

From: Methacholine bronchial provocation measured by spirometry versus wheeze detection in preschool children

Parameter

End of test

PC20-FEV1

FVC

- 41.3 ± 15.5

- 18.4 ± 10.0 *

FEV1

- 44.7 ± 14.5

- 24.6 ± 6.4 *

FEV1/FVC

- 6.09 ± 6.8

- 4.1 ± 3.8 *

PEFR

- 44.2 ± 13.2

- 21.4 ± 10.6 *

FEF50

- 61.2 ± 14.2

- 38.6 ± 16.9 *

Expiratory time (sec)

+2.8 ± 0.4

+2.2 ± 0.4 *

  1. * Changes at PC20-FEV1 are significantly lower than at "end of test", p < 0.01