Skip to main content

Table 2 Associations between CYP19A1 and PPARG methylation (%) and age at pubertal development.

From: CYP19A1 promoter methylation in saliva associated with milestones of pubertal timing in urban girls

  Unadjusted model Adjusted model*
  N HR (95% CI) p value N HR (95% CI) p value
Pubic Hair (PH2) development
CYP19A1 125 0.95 (0.90 - 0.99) 0.04 120 0.95 (0.90 - 1.00) 0.05
PPARG 129 0.99 (0.90 - 1.08) 0.75 124 0.96 (0.87 - 1.05) 0.37
Breast development (B2)
CYP19A1 125 0.97 (0.92 - 1.02) 0.17 120 0.96 (0.91 - 1.01) 0.11
PPARG 129 1.04 (0.96 - 1.13) 0.32 124 1.03 (0.94 - 1.12) 0.54
  1. *Cox proportional hazard models were adjusted for child race/ethnicity, BMI percentile, and caregiver education. Education information was missing from 5 subjects. 95% CI = 95% confidence interval.