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Table 2 Effect of various prenatal and perinatal risk factors on the severity of developmental delay

From: Predictors of severity and outcome of global developmental delay without definitive etiologic yield: a prospective observational study

  Unadjusted effect Adjusted effect
Prenatal factors   
Fecundation in vitro -0.145 -0.101
Drug exposure in pregnancy§ -0.021 -0.019
Tobacco smoke exposure in pregnancy -0.147 -0.113
Multiple gestation -0.193* -0.098
Prematurity -0.276* -0.177†
Post-term birth -0.059 -0.032
IUGR -0.301* -0.256*
Hypertensive disease of pregnancy || -0.160‡ -0.128
Hemorrhagic complications of pregnancy ¶ -0.150 -0.106
Perinatal factors   
Cesarean section -0.082 -0.049
Birth asphyxia -0.190* -0.125
Neonatal hypoxia** -0.181† -0.090
Neonatal infection -0.150 -0.089
  1. Data are standardized coefficients beta resulted by linear regression analysis. Unadjusted effect is the effect of each factor separately. Adjusted effect is the effect of each factor adjusted for the effect of the others and for socio-economic status (multiple regression model).
  2. *P <0.001; † P <0.01; ‡ P <0.05.
  3. § exposure to alcohol and illicit drugs; || preeclampsia, eclampsia; ¶ placental abruption, placenta previa; **need for ventilatory support due to respiratory distress or severe apneas;
  4. IUGR indicates intrauterine growth restriction.