Table 2 Metabolic and other laboratory assessments of 156 perinatally HIV-infected South African children at the final study visit of Neverest 2 by sex within treatment randomization group
Measurement | LPV/r (n = 85) | Â | NVP (n = 71) | Â | |||
|---|---|---|---|---|---|---|---|
| Â | Â | Boys (n = 41) | Girls (n = 44) | P-value | Boys (n = 40) | Girls (n = 31) | P-value |
Total Cholesterol, mg/dL | Mean (SD) | 170 (39) | 172 (39) | 0.816 | 163 (25) | 159 (38) | 0.533 |
 Acceptable: <170 | N (%) | 24 (58.5) | 21 (47.7) | 0.603 | 29 (72.5) | 23 (74.2) | 0.884 |
 Borderline: 170-199 | 10 (24.4) | 14 (31.8) | 8 (20.0) | 5 (16.1) | |||
 Elevated: ≥200 | 7 (17.1) | 9 (20.5) | 3 (7.5) | 3 (9.7) | |||
HDL, mg/dL | Mean (SD) | 54 (14) | 48 (12) | 0.044 | 60 (15) | 57 (16) | 0.352 |
 Abnormal: <35 | N (%) | 2 (4.9) | 5 (11.4) | 0.277 | 0 (0.0) | 2 (6.4) | 0.103 |
 Normal: ≥35 | 39 (95.1) | 39 (88.6) | 40 (100.0) | 29 (93.6) | |||
LDL, mg/dL | Mean (SD) | 98 (31) | 101 (38) | 0.664 | 89 (24) | 87 (29) | 0.738 |
 Acceptable: <110 | N (%) | 28 (68.3) | 28 (63.6) | 0.895 | 31 (77.5) | 25 (80.7) | 0.516 |
 Borderline: 110-129 | 7 (17.1) | 9 (20.5) | 7 (17.5) | 3 (9.7) | |||
 Elevated: ≥130 | 6 (14.6) | 7 (15.9) | 2 (0.5) | 3 (9.7) | |||
Total Cholesterol: HDL Ratio | Mean (SD) | 3.3 (1.0) | 3.8 (1.1) | 0.049 | 2.8 (0.7) | 3.0 (1.0) | 0.547 |
Triglycerides, mg/dL | Mean (SD) | 88 (34) | 99 (42) | 0.207 | 69 (27) | 74 (32) | 0.457 |
 Normal: ≤150 | N (%) | 37 (90.2) | 37 (84.1) | 0.398 | 39 (97.5) | 30 (96.8) | 0.855 |
 Abnormal: >150 | 4 (9.8) | 7 (15.9) | 1 (2.5) | 1 (3.2) | |||
C-Reactive Protein, mg/L | Mean (SD) | 3.2 (5.6) | 3.8 (6.5) | 0.453 | 9.5 (23.8) | 9.8 (18.1) | 0.423 |
 Normal: ≤3 | N (%) | 33 (80.5) | 36 (81.8) | 0.875 | 27 (67.5) | 19 (61.3) | 0.587 |
 Elevated: >3 | 8 (19.5) | 8 (18.2) | 13 (32.5) | 12 (38.7) | |||
Glucose, mg/dL | Mean (SD) | 96.9 (7.1) | 96.4 (7.8) | 0.736 | 97.6 (9.2) | 93.7 (8.5) | 0.070 |
 Normal: <110 | N (%) | 80 (98.8) | 41 (100.0) | 0.332 | 74 (98.7) | 39 (97.5) | 0.375 |
 Impaired: ≥110 | 1 (1.2) | 0 (0.0) | 1 (1.3) | 1 (2.5) | |||
HOMA-IR | Mean (SD) | 0.90 (0.5) | 1.16 (0.6) | 0.036 | 1.17 (1.0) | 0.96 (0.6) | 0.289 |
 Normal: ≤3.16 | N (%) | 41 (100.0) | 44 (100.0) | 1.0 | 36 (92.3) | 31 (100.0) | 0.115 |
 Resistance: >3.16 |  | 0 (0.0) | 0 (0.0) |  | 3 (7.7) | 0 (0.0) |  |