Dose of early intervention treatment during children’s first 36 months of life is associated with developmental outcomes: an observational cohort study in three low/low-middle income countries

Table 2 Treatment dose modeling results and mean mental (MDI) and psychomotor (PDI) developmental index by quintiles

Outcome	Dose indicator	Model number	Covariates	p-values		Least squares means for quintiles
				Dose^a	Covariate	Q1	Q2	Q3	Q4	Q5
MDI	Home Visits Dose	1	--	0.0443		97.8	97.9	103.5	103.5	103.1
		2	Site	0.0150	0.2159	96.3	97.0	103.3	104.4	104.2
		3	Resuscitation	0.0802	0.5155	98.1	98.1	103.5	103.4	103.2
		4	12 Mo MDI	0.0296	<0.0001	98.3	97.6	102.8	103.8	103.4
		5	12 Mo MDI	<0.0001	<0.0001	98.6	97.4	103.4	103.6	103.1
			Interaction		<0.0001
PDI	Home Visits Dose	1	--	0.0669		102.9	102.6	108.5	111.4	108.7
		2	Site	0.0823	0.1692	102.9	102.2	109.0	112.2	108.7
		3	Resuscitation	0.1160	0.5346	103.3	102.9	108.5	111.3	108.7
		4	12 Mo PDI	0.2588	0.0024	104.2	103.0	108.4	110.2	108.1
		5	12 Mo PDI	0.0030	0.0421	106.5	103.3	108.5	111.0	109.4
			Interaction		0.0135
MDI	Program Implemen-tation Dose	1	--	0.1901		100.0	98.0	101.2	104.4	102.2
		2	Site	0.2016	0.8523	100.0	98.0	101.8	104.5	102.0
		3	Resuscitation	0.2225	0.2338	100.1	98.4	101.5	104.6	102.4
		4	12 Mo MDI	0.2661	<0.0001	100.3	98.4	100.9	103.5	103.0
		5	12 Mo MDI	0.0434	0.0005	100.1	98.3	100.9	105.0	103.1
			Interaction		0.0641
PDI	Program Implemen-tation Dose	1	--	0.5182		107.4	105.4	103.6	109.6	108.1
		2	Site	0.8002	0.3009	107.1	105.8	105.1	109.5	108.0
		3	Resuscitation	0.5907	0.2590	107.5	105.9	104.0	109.7	108.2
		4	12 Mo PDI	0.7654	0.0007	108.2	105.3	104.7	108.7	107.3
		5	12 Mo PDI	0.3491	0.0011	108.6	105.3	105.5	109.6	107.2
			Interaction		0.4095

^aBold indicate significant p < .05 for the relationship between the treatment dose indicator and the developmental outcome.

ISSN: 1471-2431