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Table 2 Treatment dose modeling results and mean mental (MDI) and psychomotor (PDI) developmental index by quintiles

From: Dose of early intervention treatment during children’s first 36 months of life is associated with developmental outcomes: an observational cohort study in three low/low-middle income countries

Outcome Dose indicator Model number Covariates p-values Least squares means for quintiles
     Dosea Covariate Q1 Q2 Q3 Q4 Q5
MDI Home Visits Dose 1 -- 0.0443   97.8 97.9 103.5 103.5 103.1
2 Site 0.0150 0.2159 96.3 97.0 103.3 104.4 104.2
3 Resuscitation 0.0802 0.5155 98.1 98.1 103.5 103.4 103.2
4 12 Mo MDI 0.0296 <0.0001 98.3 97.6 102.8 103.8 103.4
5 12 Mo MDI <0.0001 <0.0001 98.6 97.4 103.4 103.6 103.1
    Interaction   <0.0001      
PDI Home Visits Dose 1 -- 0.0669   102.9 102.6 108.5 111.4 108.7
2 Site 0.0823 0.1692 102.9 102.2 109.0 112.2 108.7
3 Resuscitation 0.1160 0.5346 103.3 102.9 108.5 111.3 108.7
4 12 Mo PDI 0.2588 0.0024 104.2 103.0 108.4 110.2 108.1
5 12 Mo PDI 0.0030 0.0421 106.5 103.3 108.5 111.0 109.4
  Interaction   0.0135      
MDI Program Implemen-tation Dose 1 -- 0.1901   100.0 98.0 101.2 104.4 102.2
2 Site 0.2016 0.8523 100.0 98.0 101.8 104.5 102.0
3 Resuscitation 0.2225 0.2338 100.1 98.4 101.5 104.6 102.4
4 12 Mo MDI 0.2661 <0.0001 100.3 98.4 100.9 103.5 103.0
5 12 Mo MDI 0.0434 0.0005 100.1 98.3 100.9 105.0 103.1
    Interaction   0.0641      
PDI Program Implemen-tation Dose 1 -- 0.5182   107.4 105.4 103.6 109.6 108.1
2 Site 0.8002 0.3009 107.1 105.8 105.1 109.5 108.0
3 Resuscitation 0.5907 0.2590 107.5 105.9 104.0 109.7 108.2
4 12 Mo PDI 0.7654 0.0007 108.2 105.3 104.7 108.7 107.3
5 12 Mo PDI 0.3491 0.0011 108.6 105.3 105.5 109.6 107.2
    Interaction   0.4095      
  1. aBold indicate significant p < .05 for the relationship between the treatment dose indicator and the developmental outcome.