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Table 3 Previous reports of skin involvement in APS 1 patients

From: Cutaneous vasculitis in patients with autoimmune polyendocrine syndrome type 1: report of a case and brief review of the literature

Author and year of publication

N. of cases

Age at the onset of skin lesions (yrs)

Aspect of skin lesions

First typical component, age at onset (yrs)

Biopsy

Case series

     

Craig JM et al. 1955 [7]

1/3

2.8

erythema marginatum/recurrent skin rash

CMC, 3

increased melanin content

Betterle C et al. 1998 [2]

1/41

n.a.

n.a.

n.a.

n.a.

Perheentupa J 2006 [3]

13/91

0.7–31

fleeting maculopapular, morbilliform, or urticarial rash

n.a

2/4 biopsies revealed vasculitis

Trebušak Podkrajšek K et al. 2008 [6]

1/11

2

n.a.

HPT, 7.5

n.a.

Posovszky C et al. 2012 [15]

2/13

1

n.a.

CMC, 2.0

n.a

5

chronic recurrent urticaria

CMC, 3.0

Case reports

     

Quinto MG et al. 1964 [8]

1

0.9

multiform erythema

HPT + CMC, 4.0

n.a.

Stickler GB et al. 1965 [9]

1

7.6

evanescent trunkal macular rash

HPT + CMC, 9.1

n.a.

Spörkmann K-H et al. 1990 [10]

1

1.2

multiform erythema

HPT, 3.0

n.a.

Garty B 1998 [11]

1

22

erythema annulare centrifugum

HPT, 5

lymphohistiocytic vasculitis

Füchtenbusch M et al. 2003 [12]

1

31

purpuric subepidermal nodules progressing in deep cutaneous ulcers

HPT, 3.0

panniculitis and lymphocytic vasculitis

Kapelari K et al. 2004 [13]

1

16

photosensitive facial rash (diagnosis of systemic lupus erythematosus)

n.a.

n.a.

Hoorweg-Nijman G et al. 2008 [14]

1

1.2

n.a.

HPT, 9.0

n.a.

Montin D et al. 2008 [16]

2

1.1

urticarial rash (vasculitic rash)

CMC, 1.5

n.a.

7

urticarial rash

CMC, 7.0

Rodríguez Sánchez De La Blanca A et al. 2012 [18]

1

6

photosensitive rash

HPT, 9.0

n.a.

O’ Gorman CS et al. 2013 [17]

1

1

intermittent urticarial rash

HPT + CMC, 1

lymphocytic vasculitis

  1. CMC: chronic mucocutaneous candidiasias; HPT: chronic idiopathic hypoparathyroidism; n.a.: not available.