Figure 5From: Mandibuloacral dysplasia type A-associated progeria caused by homozygous LMNA mutation in a family from Southern China Pedigrees of the patients with MADA. Affected individuals are shown as filled black symbols, whereas heterozygous subjects are shown as a dot inside (A) . The results of sequencing LMNA gene exon9 of the affected siblings and heterozygous parents show a homozygous mutation p R527C in all of three affected siblings (B).Back to article page