Table 1 Cases of S. pyogenes endocarditis from 1940 to present for which clinical features are available
From: Two cases and a review of Streptococcus pyogenes endocarditis in children
| Casea# [ref] | Year | Age, Sex | Pre-existing cardiac abnormalities | Preceding infection | Valve(s) affected | Complications | Emboli | Surgery | Outcome |
|---|---|---|---|---|---|---|---|---|---|
| 1 [12] | 1942 | 2y, M | None | None | Mitral | • Splenomegaly | Brain, Peripheral, Renal, Spleen | No | Death |
| • Bronchopneumonia | |||||||||
| • Painful swollen joints | |||||||||
| 2 [3] | 1975 | 6 m, M | None | Meningitis | Aortic | • Microscopic hematuria | None | No | Recovered with cardiomegaly and decreased cardiac function |
| • LVHb | |||||||||
| • Aortic insufficiency and CHFc | |||||||||
| • Left sinus of Valsalva aneurysum | |||||||||
| 3 [13] | 1977 | 14y, M | VSDd closed surgically at age 6, aortic stenosis | Tonsillitis | Aortic | • Myocardial abscesses | Not reported | No | Death |
| • Rupture of sinus of Valsalva into left ventricle | |||||||||
| 4 [4] | 1980 | 16y, M | None | Febrile sore throat | Aortic | • Respiratory distress requiring intubation and ventilation | Peripheral, Renal | No | Recovered |
| • Renal failure (resolved) | |||||||||
| 5 [2] | 1984 | 2y, M | Pulmonic stenosis | None | Aortic and Mitral | • Pulmonary edema | Brain, Spleen | No | Death |
| • LVHb | |||||||||
| • Aortic insufficiency | |||||||||
| • Proliferative glomerulonephritis | |||||||||
| 6 [6] | 1988 | 4 m, F | None | Varicella | Aortic | • Para-aortic abscess | None | No | Death |
| • CHFc and pulmonary edema | |||||||||
| 7 [14] | 1988 | 4y, F | None | None | Aortic | • Polyarthritis | None | Yes | Recovered with small VSDd |
| • Aortic regurgitation | |||||||||
| • Sinus of Valsalva aneurysm | |||||||||
| 8 [7] | 1992 | 3y, F | None | None | Mitral | • Left-sided hemiparesis | Brain, Peripheral | No | Recovered with left-sided weakness and mitral regurgitation |
| • Microscopic hematuria | |||||||||
| • Mitral regurgitation | |||||||||
| • Pericardial effusion | |||||||||
| • Required vasopressors and intubation | |||||||||
| 9 [5, 15] | 1998 | 14y, M | None | None | Mitral | • Right cerebral infarction | Brain | No | Recovered with left-sided weakness |
| 10 [5] | 1999 | 5 m, M | None | Varicella | Mitral | • Seizure | Peripheral | Yes | Recovered |
| • Respiratory failure | |||||||||
| • Hypotension | |||||||||
| • Mitral regurgitation with anterior leaflet tear | |||||||||
| • Aortic root abscess | |||||||||
| • Toe autoamputation | |||||||||
| 11 [16] | 2000 | 4y, M | None | None | Mitral | • Mitral regurgitation | Left foot | Yes | Recovered |
| • Necrosis of 2 toes requiring amputation | |||||||||
| 12 [16] | 2000 | 2y, M | None | Varicella | Aortic | • Aortic root abscess | Brain, Peripheral | Yes | Recovered with left hemiplegia |
| • Aortic valve perforation | |||||||||
| • Focal seizures | |||||||||
| 13 [8] | 2000 | 3y, M | None | Varicella | Aortic | • Joint pain | Peripheral | Yes | Recovered |
| • Bilateral pulmonary infiltrates | |||||||||
| • Elevated LFTse | |||||||||
| • Aortic insufficiency | |||||||||
| • Left ventricular dilatation leading to CHFc |
