Table 2 Neonatal data and routine laboratory at the first day of life according to F7 -genotype (median with range and percentages, respectively)
F7-323Ins10 wildtype (wt/wt) (n = 68) | F7-323Ins10 carrier (wt/10 + 10/10) (n = 18 + 0) | p-value | |
|---|---|---|---|
Gestational age [weeks + days] | 27 + 6 (23 + 3 - 31 + 5) | 28 + 5 (25 + 2 - 30 + 6) | 0.656 |
Birth weight [g] | 990 (320–2005) | 990 (405–2270) | 0.255 |
Male [%] | 66.2 | 73.7 | 0.593 |
IVH [%] | 18.3 | 21.1 | 0.750/*0.649 |
Prenatal steroids [%] | 65.7 | 73.7 | 0.591 |
Surfactant [%] | 81.7 | 89.5 | 0.729 |
CPAP [%] | 87.3 | 94.7 | 0.682 |
Intubation [%] | 40.8 | 42.1 | 1.000 |
PDA medicament [%] | 77.5 | 84.2 | 0.753 |
PDA OP [%] | 7.0 | 0.0 | 0.580 |
Sepsis [%] | 11.3 | 5.3 | 0.678 |
Apgar 5 min | 8 (5–10) | 8 (2–9) | 0.444 |
CRIB-Score | 4 (0–16) | 1.5 (1–8) | 0.108 |
Il-6 [pg/ml] | 42.3 (2.0 - 689,002.0) | 102.0 (10.5 - 5140.0) | 0.326 |
CRP [mg/l] | 0.2 (0.2 - 78.2) | 0.2 (0.2 - 35.0) | 0.917 |
Hematocrit [%] | 46.0 (10.7 - 59.0) | 43.0 (31.0 - 59.0) | 0.452 |
Leucocytes [×103/μl] | 7.08 (1.08 - 32.00) | 7.70 (3.29 - 26.25) | 0.353 |
Thrombocytes [×103/μl] | 157 (15–278) | 170 (75–291) | 0.174 |
FII [activity in%] | 34 (17–65) | 29 (23–45) | 0.236/*0.107 |
FVII [activity in%] | 34 (7–93) | 29 (12–48) | 0.052/*0.028 |
FX [activity in%] | 45 (23–89) | 33 (14–58) | 0.340/*0.013 |
ATIII [activity in%] | 30 (13–51) | 29.5 (16–48) | 0.903/*0.799 |