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Table 5 The effect of VAS/OPV on anthropometric parameters at baseline, 4 weeks, and 6 months after enrolment

From: Neonatal vitamin A supplementation associated with a cluster of deaths and poor early growth in a randomised trial among low-birth-weight boys of vitamin A versus oral polio vaccine at birth

 

Baseline

4 weeks

6 months

 

VAS

OPV

Difference#/GMR¤

RR

VAS

OPV

Difference#/GMR¤

RR

VAS

OPV

Difference

RR

 

N = 77

N = 82

(95% CI)

(95% CI)

N = 63

N = 66

(95% CI)

(95% CI)

N = 67

N = 73

(95% CI)

(95% CI)

Age, days

2

2

  

32

34

  

183

183

  

Length,

44.9

45.2

0.99¤

 

48.3

49.5

0.45¤

 

63.0

63.6

-0.32

 

cm*

  

(0.98-1.01)

   

(0.17-1.16)

   

(-1.31;0.67)

 

LAZ*

-3.01

-2.84

-0.17#

 

-3.38

-2.89

-0.28#

 

-2.16

-1.93

-0.13

 
   

(-0.54;0.20)

   

(-0.77;0.22)

   

(-0.59;0.34)

 

Stunted*

85%

72%

 

1.19

86%

74%

 

1.12

55%

37%

 

1.49

    

(1.00-1.40)

   

(0.94-1.33)

   

(0.98-2.23)

Weight,

2.05

2.13

0.96¤

 

2.84

3.10

-0.26 #

 

6.51

6.57

-0.06

 

kg

  

(0.92-1.01)

   

(-0.46;-0.07)

   

(-0.43;0.31)

 

WAZ

-2.95

-2.73

-0.20#

 

-3.31

-3.00

-0.46 #

 

-3.20

-3.06

-0.11

 
   

(-0.47;0.08)

   

(-0.88;-0.04)

   

(-0.61;0.39)

 

Under-

97%

99%

 

0.99

87%

73%

 

1.20

48%

29%

 

1.68

weight

   

(0.94-1.03)

   

(1.01-1.43)

   

(1.04-2.73)

HC, cm

31.0

31.3

-0.27#

 

35.3

35.6

-0.22#

 

42.6

42.8

-0.16

 
   

(-0.85;0.31)

   

(-0.76;0.32)

   

(-0.72;0.40)

 

HCAZ

-3.11

-2.89

-0.22#

 

-1.86

-1.47

-0.09#

 

-0.55

-0.43

-0.13

 
   

(-0.71;0.26)

   

(-0.55;0.37)

   

(-0.58;0.33)

 

MUAC,

7.7

7.9

0.80¤

 

9.4

10.1

-0.50 #

 

13.9

14.1

-0.21

 

cm

  

(0.63-1.02)

   

(-0.93;-0.07)

   

(-0.65;0.23)

 

ACAZ

-

-

  

-

-

-

 

-0.35

-0.15

-0.19

 
           

(-0.62;0.23)

 
  1. *Length measures are adjusted for being stunted at baseline.
  2. ¤Geometric mean ratio (GMR) is provided for non-normally distributed data, #Difference for normally distributed data.
  3. Abbreviations: RR relative risk; LAZ length-for-age z-score; WAZ weight-for-age z-score; HC head circumference; HCAZ head circumference-for-age z-score; MUAC middle upper arm circumference; ACAZ Arm circumference-for-age z-score.
  4. Significant values in bold .