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Table 5 Prevalence of all forms of otitis media including combination categories, by vaccination groups

From: Otitis media in children vaccinated during consecutive 7-valent or 10-valent pneumococcal conjugate vaccination schedules

  PCV7 444 PHiD-CV10 451 Absolute risk difference [95%CI] P value
  n % n %
No. children without assessment 12 3% 14 3%   
No. children with diagnosis based on tympanometry alone 4 1% 0 0%   
No. children with unilateral otoscopy 27 6% 13 3%   
No. children with bilateral otoscopy 401 90% 424 94%   
No. children with at least one ear successfully assessed 432 97% 437 97%   
Clinical diagnosis PCV7 432 PHiD-CV10 437   
normal 32 7% 41 9% 2% [−1 to 6] 0.29
OME 175 41% 222 51% 10% [3-17] 0.002
AOMwoP 150 35% 111 25% −9% [−15 to −3] 0.003
AOMwiP 27 6% 24 5% −1% [−4 to 2] 0.63
Dry Perforation 8 2% 5 1% −0.7% [−2 to 1] 0.39
CSOM 40 9% 34 8% −1% [−5 to 2] 0.43
Bilateral OME* 136/401 34% 191/424 45% 11% [4-17] 0.001
Unilateral OME* 24/401 6% 25/424 6% 0.1% [−3 to 3] 1.000
Combination OM categories       
Any suppurative OM (AOMwoP, AOMwiP, CSOM) 217 51% 169 39% −12% [−19 to −5] 0.0004
Any TMP (AOMwiP, DP, CSOM) 75 17% 63 14% −3% [−8 to 2] 0.24
Any ear pain (today or last night) 34/408 8% 17/337 5% −3% [−7 to 0.2] 0.08
Non-mixed PCV schedules PCV7-only 353** PHiD-CV10-only 319   
No. children with at least one ear successfully assessed 345 98% 309 97%   
Normal 24 7% 31 10% 3% [−1 to 7] 0.16
OME 127 37% 152 49% 12% [5 to 20] 0.001
Any suppurative OM (AOMwoP, AOMwiP, CSOM) 191 56% 121 40% −16% [−24 to −8] <0.0001
Any TMP (AOMwiP, DP, CSOM) 62 18% 48 16% −2% [−8 to 3] 0.40
  1. *Laterality of OME could only be determined where bilateral assessments were successful; 401 PCV7 children and 424 PHiD-CV10 children had bilateral assessments.
  2. **138 children in the PCV7-only group had also received PPV23.