Perinatal mortality in pregnancies with omphalocele: data from the Chinese national birth defects monitoring network, 1996–2006

Table 3 Association with perinatal mortality of omphaloceles by the selected fetal characteristics, China, 1996-2006

	Total N	Late fetal death				Early neonatal death
	Total N	No.	Rate* (95% CI)	COR (95% CI)	AOR^†(95% CI)	No.	Rate * (95% CI)	COR (95% CI)	AOR^†(95% CI)
Gestational age ^$ (weeks)
37–42	436	83	19.0 (15.4, 22.7)	Ref.	Ref.	74	17.0 (13.4, 20.5)	Ref.	Ref.
28–36	388	224	57.7 (52.8, 62.6)	6.61 (4.73, 9.22)	2.42 (1.52, 3.86)	50	12.9 (9.6, 16.2)	1.65 (1.09, 2.52)	1.18 (0.72, 1.96)
Birthweight ^# (g)
≥2500	428	80	18.7 (15.0, 22.4)	Ref.	Ref.	65	15.2 (11.8, 18.6)	Ref.	Ref.
<2500	395	226	57.2 (52.3, 62.1)	7.20 (5.15, 10.83)	3.17 (1.97, 5.09)	58	14.7 (11.2, 18.2)	2.28 (1.50, 3.45)	1.72 (1.04, 2.82)
Non-isolated omphalocele
No	596	198	33.2 (29.4, 37.0)	Ref.	Ref.	76	12.8 (10.1, 15.4)	Ref.	Ref.
Yes	231	111	48.1 (41.6, 54.5)	2.51 (1.78, 3.54)	2.64 (1.62, 4.29)	48	20.8 (15.5, 26.0)	2.82 (1.81, 4.40)	2.96 (1.82, 4.81)
Prenatal ultrasound diagnosis ^§
No	498	70	14.1 (11.0, 17.1)	Ref.	Ref.	99	19.9 (16.4, 23.4)	Ref.	Ref.
Yes	322	235	73.0 (68.1, 77.8)	17.81 (12.17, 26.06)	15.91 (10.18, 24.87)	25	7.8 (4.8, 10.7)	1.34 (0.80, 2.25)	1.42 (0.81, 2.50)

^*Rate is the number of death per 100 fetus and neonates with omphalocele from 28 weeks of gestations to the first 7 days of life.
^†ORs were adjusted by geographical location, maternal residence, maternal age, maternal education, gestational age, birthweight, non-isolated omphalocele and diagnosis by prenatal ultrasonography.
^$Three cases with unknown gestation age were excluded from this analysis.
^#Four cases with unknown birthweight were excluded from this analysis.
^§Seven cases with unknown prenatal ultrasound diagnosis were excluded from this analysis.
COR, crude odds ratio; AOR, adjusted odds ratio; CI, confidence interval; Ref., reference group.

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