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Table 3 Comparison of various markers of dehydration in two cohorts

From: Comparison of clinical and biochemical markers of dehydration with the clinical dehydration scale in children: a case comparison trial

Markers

Dehydrated n = 73

Comparison n = 143

AUC (SE)

P value

Dehydration score

3 (0–8)

0 (0–0)

 

<0.0001

Pre-hydration systolic blood pressure z-score

0.57 (-0.18-1.54)

0.97 (0.02-1.90)

 

n.s.

Pre-hydration diastolic blood pressure z-score

0.67 (-0.09-1.21)

0.24 (-0.42, 1.10)

 

n.s.

Pre-hydration heart rate

134 (112, 158)

97 (84, 130)

 

<0.0001

Urine Na/K ratio [17]

0.69 (0–4.4)

2.3(0–56)

0.789(0.03)

<0.0001

Serum Osmolality [mOsm] [18]

286 (231–684)

289 (199–391)

 

0.11

Urine Na [mmol/L] [19]

66.0 ± 55.6

144 ± 74

0.798(0.03)

<0.0001

FeNa [20]

0.19 (0–0.89)

0.52 (0–10.4)

0.753(0.03)

<0.0001

FeUrea [21]

0.398 (0.678-0.96)

0.377 (0.055-4.504)

 

n.s.

Serum bicarbonate [mmol/L]

20 (10–27)

24 (18–30)

0.821(0.03)

<0.0001

Blood urea [g/L]

5.7 (1.2-41)

5 (2.6-9.2)

0.613(0.05)

0.01

Serum creatinine [μmol/L]

38 (16–408)

45 (3.8-97)

0.666(0.04)

0

Schwartz eGFR [mL/min/1.73 m 2 ]

131.6 ± 32.3

136.9 ± 23.2

 

0.18

Cystatin C [mg/L]

0.67 (0.43-2.89)

0.66 (0.44-1.08)

 

n.s.

Cystatin C eGFR [mL/min/1.73 m 2 ]

144.0 ± 36.9

147.6 ± 25.1

 

n.s.

Urine osmolality [mOsm]

805 ± 306

876 ± 402

 

0.2

Urinary microalbumin/creatinine ratio [mg/mmol] [22]

4.4 (0.4-61.1)

2.3 (0.3-9.4)

0.69 (0.04)

<0.0001

Urinary α1-microglobulin/creatinine ratio [mg/mmol] [22]

1.75 (0.30-14.70)

0.70 (0.20-11.30)

0.809(0.04)

P < 0.001

  1. Student’s t-test or Mann Whitney test of established and potential markers of dehydration and acute kidney injury with key references listed. Data are expressed as mean and one standard deviation or median and range, as appropriate based on the distribution. “n.s.” means not significant. Results are expressed as median (range) or mean ± standard deviation where applicable. Urine Na/K ratio, urine Na, FeNa, serum bicarbonate, serum creatinine and blood urea were all significantly different. FeNa = [urine sodium (mmol/L) × plasma creatinine (μmol/L)] / (plasma sodium (mmol/L) ÷ urine creatinine(μmol/L)] × 100. AUC = Receiver operating characteristic curves area under the curves. SE = standard error.