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Table 1 Cytokine profiles of serum, plasma and ascites

From: The first report of adolescent TAFRO syndrome, a unique clinicopathologic variant of multicentric Castleman’s disease

   Serum Ascites Reference range
   On admission Day 17 (before weekly TCZ) Day 321 Day 29 Day 36 Serum
IL-1α pg/mL <1.37 <1.37 <1.37 <1.37 <1.37 0.29–62.1
IL-1β pg/mL <0.640 <0.640 <0.640 1.620 0.826 0.11–24.3
IL-2 pg/mL <1.78 <1.78 <1.78 6.84 2.00 0.22–2.68
IL-4 pg/mL 0.542 0.376 0.642 2.90 3.84 N.A.
IL-5 pg/mL <3.2 <3.2 <3.2 6.70 5.72 0.11–0.62
IL-6 pg/mL 29 5.0 5.0 4400 4700 <3
IL-7 pg/mL 146 54.6 89.0 17.6 20.8 0.37–2.78
IL-8 pg/mL 230 348 34.8 >798 522 1.48–1720
IL-10 pg/mL 3.28 23.2 1.36 8.00 10.4 0.06–3.08
IL-12p70 pg/mL 3.40 3.16 3.20 5.30 31.0 0.26–0.38
IL-12/IL-23p40 pg/mL 488 49.2 330 45.2 93.6 13.1–159
IL-13 pg/mL 6.98 8.28 8.90 17.0 12.0 0.60–2.78
IL-15 pg/mL 11.6 36.8 4.74 34.8 43.6 0.56–3.01
IL-16 pg/mL 1054 1266 628 366 610 24–137
IL-17A pg/mL <17.7 <17.7 <17.7 <17.7 <17.7 0.28–4.87
IL-18 pg/mL 360 230 182 75.0 80.0 <500
IFN-γ pg/mL 14.8 <5.12 22.2 19.3 10.7 0.64–14.4
TNF-α pg/mL <5 <5 N.D. <5 <5 <5
sTNF-RI pg/mL 7300 10200 1230 8000 4800 484–1407
sTNF-RII pg/mL 9600 21800 3450 6000 4200 829–2262
VEGF pg/mL N.D. 178* 16.4* 1860 1210 <38.3*
Neopterin nmol/L 10.0 28.5 4.00 16.7 15.5 <5
GM-CSF pg/mL <3.8 <3.8 <3.8 <3.8 <3.8 0.18–0.18
IP-10 pg/mL >2000 >2000 928 1200 1440 28.5–237
MIP-1α pg/mL 87.6 56.0 <55.2 71.6 77.2 12–202
MIP-1β pg/mL 628 480 452 166 188 7.29–95.2
Eotaxin pg/mL 76.8 <48.8 228 85.6 162 19.0–145
Eotaxin-3 pg/mL 61.2 68.0 76.0 404 624 7.63–8.73
TARC pg/mL 132 58.8 860 30.2 33.2 5.39–70.0
MCP-1 pg/mL >1508 528 632 >1508 >1508 75.7–205
MCP-4 pg/mL 180 47.2 209 36.2 39.2 11.2–117
MDC pg/mL 1960 330 2740 <320 374 606–3249
  1. IL: interleukin; IFN: interferon; TNF: tumor necrosis factor; sTNF-RI: soluble tumor necrosis factor receptor type I; sTNF-RII: soluble tumor necrosis factor receptor type II; VEGF: vascular endothelial cell growth factor; GM-CSF: granulocyte macrophage colony-stimulating factor; IP-10: interferon gamma-induced protein 10; MIP: macrophage inflammatory protein; TARC: thymus and activation regulated chemokine; MCP: monocyte chemoattractant protein; MDC: macrophage-derived chemokine; N.A: not available; N.D: not determined: *: values derived from plasma.