Table 1 Cytokine profiles of serum, plasma and ascites
Serum | Ascites | Reference range | |||||
|---|---|---|---|---|---|---|---|
On admission | Day 17 (before weekly TCZ) | Day 321 | Day 29 | Day 36 | Serum | ||
IL-1α | pg/mL | <1.37 | <1.37 | <1.37 | <1.37 | <1.37 | 0.29–62.1 |
IL-1β | pg/mL | <0.640 | <0.640 | <0.640 | 1.620 | 0.826 | 0.11–24.3 |
IL-2 | pg/mL | <1.78 | <1.78 | <1.78 | 6.84 | 2.00 | 0.22–2.68 |
IL-4 | pg/mL | 0.542 | 0.376 | 0.642 | 2.90 | 3.84 | N.A. |
IL-5 | pg/mL | <3.2 | <3.2 | <3.2 | 6.70 | 5.72 | 0.11–0.62 |
IL-6 | pg/mL | 29 | 5.0 | 5.0 | 4400 | 4700 | <3 |
IL-7 | pg/mL | 146 | 54.6 | 89.0 | 17.6 | 20.8 | 0.37–2.78 |
IL-8 | pg/mL | 230 | 348 | 34.8 | >798 | 522 | 1.48–1720 |
IL-10 | pg/mL | 3.28 | 23.2 | 1.36 | 8.00 | 10.4 | 0.06–3.08 |
IL-12p70 | pg/mL | 3.40 | 3.16 | 3.20 | 5.30 | 31.0 | 0.26–0.38 |
IL-12/IL-23p40 | pg/mL | 488 | 49.2 | 330 | 45.2 | 93.6 | 13.1–159 |
IL-13 | pg/mL | 6.98 | 8.28 | 8.90 | 17.0 | 12.0 | 0.60–2.78 |
IL-15 | pg/mL | 11.6 | 36.8 | 4.74 | 34.8 | 43.6 | 0.56–3.01 |
IL-16 | pg/mL | 1054 | 1266 | 628 | 366 | 610 | 24–137 |
IL-17A | pg/mL | <17.7 | <17.7 | <17.7 | <17.7 | <17.7 | 0.28–4.87 |
IL-18 | pg/mL | 360 | 230 | 182 | 75.0 | 80.0 | <500 |
IFN-γ | pg/mL | 14.8 | <5.12 | 22.2 | 19.3 | 10.7 | 0.64–14.4 |
TNF-α | pg/mL | <5 | <5 | N.D. | <5 | <5 | <5 |
sTNF-RI | pg/mL | 7300 | 10200 | 1230 | 8000 | 4800 | 484–1407 |
sTNF-RII | pg/mL | 9600 | 21800 | 3450 | 6000 | 4200 | 829–2262 |
VEGF | pg/mL | N.D. | 178* | 16.4* | 1860 | 1210 | <38.3* |
Neopterin | nmol/L | 10.0 | 28.5 | 4.00 | 16.7 | 15.5 | <5 |
GM-CSF | pg/mL | <3.8 | <3.8 | <3.8 | <3.8 | <3.8 | 0.18–0.18 |
IP-10 | pg/mL | >2000 | >2000 | 928 | 1200 | 1440 | 28.5–237 |
MIP-1α | pg/mL | 87.6 | 56.0 | <55.2 | 71.6 | 77.2 | 12–202 |
MIP-1β | pg/mL | 628 | 480 | 452 | 166 | 188 | 7.29–95.2 |
Eotaxin | pg/mL | 76.8 | <48.8 | 228 | 85.6 | 162 | 19.0–145 |
Eotaxin-3 | pg/mL | 61.2 | 68.0 | 76.0 | 404 | 624 | 7.63–8.73 |
TARC | pg/mL | 132 | 58.8 | 860 | 30.2 | 33.2 | 5.39–70.0 |
MCP-1 | pg/mL | >1508 | 528 | 632 | >1508 | >1508 | 75.7–205 |
MCP-4 | pg/mL | 180 | 47.2 | 209 | 36.2 | 39.2 | 11.2–117 |
MDC | pg/mL | 1960 | 330 | 2740 | <320 | 374 | 606–3249 |