DoMINO: Donor milk for improved neurodevelopmental outcomes

Unger, Sharon; Gibbins, Sharyn; Zupancic, John; O’Connor, Deborah L

doi:10.1186/1471-2431-14-123

BMC Pediatrics

Table 2 Breastmilk components and the effect of pasteurization

From: DoMINO: Donor milk for improved neurodevelopmental outcomes

Component	Effect	References
Adiponectin	33% reduction	[43]
Amylase	15% loss of activity	[44]
B-cells, T-cells	Abolished	[45, 46]
Bile salt dependent lipase	Abolished	[44]
CD14 (soluble)	88% reduction	[47]
Fats:
Total fat	No effect	[48–50]
C14:1-C24:1	No effect	[44, 49]
C8:0-C24:0	No effect	[44, 49]
n-3,n-6 PUFA	No effect	[44, 49]
AA, DHA	No effect	[44, 49]
Linoleic, linolenic	Reduced	[51]
Calcium	No effect	[48]
Copper	9% reduction No effect	[50, 52]
Escherichia coli inhibition	26% reduction	[53]
Epidermal growth factor	No effect	[54, 55]
Erythropoeitin	Significantly reduced	[56]
Folate	16-31% reduction	[41, 42]
Free fatty acids	80% increase	[57]
Gangliosides	No effect	[54]
Hepatocyte growth factor	60% reduction	[54]
Immunoglobulins:
IgA, sIgA	0-48% reduction	[45, 46, 48, 58–62]
IgG	34% reduction	[60]
IgM	Abolished	[61, 62]
Insulin	46% reduction	[43]
IGF-1, IGF-2, IGF-BP2,3	7-39% reduction	[55]
IL-1β, IL-10	Significantly reduced	[54, 56]
IL-2, Il-4, IL-5, IL-12, IL-13	No effect	[54]
IL-8	Increased	[54]
Interferon gamma	Significantly reduced	[54]
Iron	0-15% reduction	[50, 52]
Lactate	7% reduction	[57]
Lactoferrin	57-80% reduction	[58, 60, 61]
Lactose	No effect	[48, 50]
Lipoprotein lipase	Abolished	[44]
Lysine	Significantly reduced	[61, 63]
Lysozyme activity	No effect 24-60% reduction	[58–62]
Lymphocytes	Abolished	[46]
Magnesium	No effect	[48]
Mannose-binding lectin	No effect	[47]
Oligosaccharides	No effect	[64]
Phosphorus	No effect	[48]
Potassium	No effect	[48]
Protein	No effect Reduced	[43, 48, 50, 62]
Sodium	No effect	[48, 50]
TGF-α, TGF-β	No effect Reduced	[54, 65]
Vitamin A	No effect	[50]
Vitamin B6	15% reduction	[42]
Vitamin C	36% reduction	[42]
Zinc	0-3% reduction	[50, 52]

Modified with permission from: Ewaschuk JB, Unger S, Harvey S, O’Connor DL, Field CJ. Effect of pasteurization on immune components of milk: implications for feeding preterm infants. Applied Physiology, Nutrition, and Metabolism 36:175–182, 2011.

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ISSN: 1471-2431

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