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Table 2 Breastmilk components and the effect of pasteurization

From: DoMINO: Donor milk for improved neurodevelopmental outcomes

Component Effect References
Adiponectin 33% reduction [43]
Amylase 15% loss of activity [44]
B-cells, T-cells Abolished [45, 46]
Bile salt dependent lipase Abolished [44]
CD14 (soluble) 88% reduction [47]
Fats:   
 Total fat No effect [4850]
 C14:1-C24:1 No effect [44, 49]
 C8:0-C24:0 No effect [44, 49]
 n-3,n-6 PUFA No effect [44, 49]
 AA, DHA No effect [44, 49]
 Linoleic, linolenic Reduced [51]
Calcium No effect [48]
Copper 9% reduction No effect [50, 52]
Escherichia coli inhibition 26% reduction [53]
Epidermal growth factor No effect [54, 55]
Erythropoeitin Significantly reduced [56]
Folate 16-31% reduction [41, 42]
Free fatty acids 80% increase [57]
Gangliosides No effect [54]
Hepatocyte growth factor 60% reduction [54]
Immunoglobulins:   
 IgA, sIgA 0-48% reduction [45, 46, 48, 5862]
 IgG 34% reduction [60]
 IgM Abolished [61, 62]
Insulin 46% reduction [43]
IGF-1, IGF-2, IGF-BP2,3 7-39% reduction [55]
IL-1β, IL-10 Significantly reduced [54, 56]
IL-2, Il-4, IL-5, IL-12, IL-13 No effect [54]
IL-8 Increased [54]
Interferon gamma Significantly reduced [54]
Iron 0-15% reduction [50, 52]
Lactate 7% reduction [57]
Lactoferrin 57-80% reduction [58, 60, 61]
Lactose No effect [48, 50]
Lipoprotein lipase Abolished [44]
Lysine Significantly reduced [61, 63]
Lysozyme activity No effect 24-60% reduction [5862]
Lymphocytes Abolished [46]
Magnesium No effect [48]
Mannose-binding lectin No effect [47]
Oligosaccharides No effect [64]
Phosphorus No effect [48]
Potassium No effect [48]
Protein No effect Reduced [43, 48, 50, 62]
Sodium No effect [48, 50]
TGF-α, TGF-β No effect Reduced [54, 65]
Vitamin A No effect [50]
Vitamin B6 15% reduction [42]
Vitamin C 36% reduction [42]
Zinc 0-3% reduction [50, 52]
  1. Modified with permission from: Ewaschuk JB, Unger S, Harvey S, O’Connor DL, Field CJ. Effect of pasteurization on immune components of milk: implications for feeding preterm infants. Applied Physiology, Nutrition, and Metabolism 36:175–182, 2011.