Skip to main content

Table 2 CMV-specific testing a by presence or absence of a code for CMV-associated conditions among infants ≤1 month of age and infants with routine laboratory testing, MarketScan 2011 bc

From: Laboratory testing and diagnostic coding for cytomegalovirus among privately insured infants in the United States: a retrospective study using administrative claims data

CMV-associated conditionc Infants
N=368,266
Infants with Routine Laboratory Testingd
N=38,344
Total Tested P-value Total Tested P-value
# # (%) # # (%)
Chorioretinitis       
  No 368,253 229 (0.06) 1.00 38,340 129 (0.34) 1.00
  Yes 13 0 (0.00)   4 0 (0.00)  
Encephalitis       
  No 368,254 229 (0.06) 1.00 38,344 129 (0.34) NA
  Yes 12 0 (0.00)   0   
Hepatomegaly       
  No 368,221 224 (0.06) <0.01 38,336 126 (0.33) <0.01
  Yes 45 5 (11.11)   8 3 (37.50)  
Jaundice       
  No 257,269 175 (0.07) 0.03 24,584 92 (0.37) 0.09
  Yes 110,997 54 (0.05)   13,760 37 (0.27)  
Low Birth Weight       
  No 334,333 90 (0.03) <0.01 34,570 46 (0.13) <0.01
  Yes 33,933 139 (0.41)   3,774 83 (2.20)  
Microcephaly       
  No 368,151 224 (0.06) <0.01 38,328 127 (0.33) <0.01
  Yes 115 5 (4.35)   16 2 (12.50)  
Other Congenital Anomalies of Nervous System       
  No 367,278 205 (0.06) <0.01 38,206 116 (0.30) <0.01
  Yes 988 24 (2.43)   138 13 (9.42)  
Petechiae       
  No 366,616 228 (0.06) 1.00 38,134 129 (0.34) 1.00
  Yes 1,650 1 (0.06)   210 0 (0.00)  
Seizures       
  No 367,209 208 (0.06) <0.01 38,210 116 (0.30) <0.01
  Yes 1,057 21 (1.99)   134 13 (9.70)  
Splenomegaly       
  No 368,256 229 (0.06) 1.00 38,343 129 (0.34) 1.00
  Yes 10 0 (0.00)   1 0 (0.00)  
Thrombocytopenia       
  No 367,146 193 (0.05) <0.01 38,156 108 (0.28) <0.01
  Yes 1,120 36 (3.21)   188 21 (11.17)  
Any of the above 11 CMV-associated conditions       
  No 231,409 42 (0.02) <0.01 21,968 19 (0.09) <0.01
  Yes 136,857 187 (0.14)   16,376 110 (0.67)  
  1. a CMV-specific testing includes CMV serologic testing (CMV IgG, CMV IgM, and CMV EIA), CMV DFA, and CMV PCR testing. (See Additional file 1: Table S1 for CPT codes).
  2. bInfants are defined as enrollees ≤ 1 month of age with ≥1 medical claim within 30 days of a newborn code (defined as either a code for live birth, or observation and evaluation of newborns and infants; codes defined in Additional file 1: Table S1).
  3. cSee Additional file 1: Table S1 for ICD-9-CM and CPT codes used to identify CMV-associated conditions.
  4. d Infants with ≥1 codes for other routinely recommended laboratory tests that are typically performed on infants as part of standard care. These tests included phenylketonuria, hypothyroidism, galactosemia, and hemoglobinopathies.