Laboratory testing and diagnostic coding for cytomegalovirus among privately insured infants in the United States: a retrospective study using administrative claims data

Table 1 Presence of a code for CMV-associated conditions ^a among all infants, infants with CMV-specific testing, infants with non-specific testing, and infants with a diagnostic code for CMV, MarketScan 2011 ^b

CMV-associated condition^a	All Infants	Infants with CMV-specific testing^c	Infants with Non-specific testing^d	Infants with an ICD-9-CM code for congenital CMV infection or CMV disease
	N=368,266	N=229	N=1,091	N=61
	# (%)	# (%)	# (%)	# (%)
Chorioretinitis	13 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)
Encephalitis	12 (0.0)	0 (0.0)	3 (0.3)	0 (0.0)
Hepatomegaly	45 (0.1)	5 (2.2)	1 (0.1)	0 (0.0)
Jaundice	110,997 (30.1)	54 (23.6)	361 (33.1)	11 (18.0)
Low Birth Weight	33,933 (9.2)	139 (60.7)	266 (24.4)	24 (39.3)
Microcephaly	115 (0.0)	5 (2.2)	7 (0.6)	3 (4.9)
Other Congenital Anomalies of Nervous System	988 (0.3)	24 (10.5)	28 (2.6)	4 (6.6)
Petechiae	1,650 (0.5)	1 (0.4)	2 (0.2)	1 (1.6)
Seizures	1,057 (0.3)	21 (9.2)	55 (5.0)	4 (6.6)
Splenomegaly	10 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)
Thrombocytopenia	1,120 (0.3)	36 (15.7)	40 (3.7)	5 (8.2)
Any of the above 11 CMV-associated conditions	136,857 (37.2)	187 (81.7)	599 (54.9)	37 (60.7)
None of the above 11 CMV-associated conditions	231,409 (62.8)	42 (18.3)	492 (45.1)	24 (39.3)

^aSee Additional file 1: Table S1 for ICD-9-CM and CPT codes used to identify CMV-associated conditions.
^bInfants are defined as enrollees ≤ 1 month of age with ≥1 medical claim within 30 days of a newborn code (defined as either a code for live birth, or observation and evaluation of newborns and infants; codes defined in Additional file 1: Table S1).
^cCMV-specific testing includes CMV serologic testing (CMV IgG, CMV IgM, and CMV EIA), CMV DFA, and CMV PCR testing. (See Additional file 1: Table S1 for CPT codes).
^dNon-specific testing includes viral culture, molecular diagnostics, or infectious agent detection. (See Additional file 1: Table S1 for CPT codes).

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