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Table 5 Predicting abnormal aEEG at 3 or 6 hours: assessments at 1 and 3 – 5 hours

From: Early clinical signs in neonates with hypoxic ischemic encephalopathy predict an abnormal amplitude-integrated electroencephalogram at age 6 hours

Encephalopathy assessment method

n

Abnormal aEEG n (%)

Sensitivity (95%CI)

Specificity (95%CI)

LR +(95%CI)

LR - (95%CI)

LR Test (Odds ratio) (95%CI)

Moderate-severe encephalopathy age 1 hour

Yes

31

25 (81)

89%

60%

2.23

0.18

12.5

No

12

3 (25)

(72 – 98)

(32 – 84)

(1.19 – 4.2)

(0.06 – 0.56)

(2.71 – 56.89)

Moderate-severe encephalopathy age 3 – 5 hours

Yes

29

26 (90)

93%

80%

4.64

0.09

52

No

14

2 (14)

(77 – 99)

(52 – 96)

(1.68 – 12.84)

(0.02 – 0.35)

(8.24 – 321.56)

Thompson score ≥ 8 age 3 – 5 hours

Yes

28

25 (89)

89%

80%

4.46

0.13

33.33

No

15

3 (20)

(72 – 98)

(52 – 96)

(1.61 – 12.38)

(0.04 – 0.4)

(6.16 – 180.87)

Thompson score ≥ 7 age 3 – 5 hours

Yes

31

26 (84)

93%

67%

2.79

0.11

26

No

12

2 (17)

(77 – 99)

(38 – 88)

(1.35 – 5.74)

(0.03 – 0.43)

(4.67 – 139.13)

Thompson score ≥ 6 age 3 – 5 hours

Yes

34

26 (76)

93%

47%

1.74

0.15

11.38

No

9

2 (22)

(77 – 99)

(21 – 73)

(1.07 – 2.83)

(0.04 – 0.65)

(2.15 – 57.78)

Thompson score ≥ 5 age 3 – 5 hours

Yes

39

28 (72)

100%

27%

1.37 a

0.06 a

22.3 a

No

4

0 (0)

(88 – 100)

(8 – 55)

(1 – 1.86)

(0 – 1.07)

(1.11 – 448.4)

Thompson score ≥ 8 age 3 – 5 hours

Yes

30

26 (87)

93%

73%

3.48

0.1

35.75

No

13

2 (15)

(77 – 99)

(45 – 92)

(1.5 – 8.11)

(0.02 – 0.38)

(6.13 – 201.31)

Thompson score ≥ 7 age 3 – 5 hours

Yes

32

27 (84)

96%

67%

2.76 a

0.08 a

35 a

No

11

1 (9)

(82 – 100)

(38 – 88)

(1.39 – 5.46)

(0.02 – 0.39)

(5.03 – 243.64))

Thompson score ≥ 6 age 1 hour

Yes

38

28 (74)

100%

33%

1.5 a

0.05 a

29.86 a

No

5

0 (0)

(88 – 100)

(12 – 62)

(1.05 – 2.14)

(0 – 0.85)

(1.52 – 587.98)

Thompson score ≥ 5 age 1 hour

Yes

39

28 (72)

100%

27%

1.37 a

0.06 a

22.3 a

 

No

4

0 (0)

(88 – 100)

(8 – 55)

(1 – 1.86)

( 0 – 1.07)

(1.11 – 448.4)

  1. aEEG: amplitude integrated electro-encephalogram, LR: Likelihood ratio.
  2. a : When zero count cells are present, LR is estimated using a substitution formula: 0.5 is added to all cell frequencies before calculation.
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BMC Pediatrics

ISSN: 1471-2431

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