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Table 3 Prediction of abnormal 6-hour aEEG with different encephalopathy assessment methods at 3 – 5 hours

From: Early clinical signs in neonates with hypoxic ischemic encephalopathy predict an abnormal amplitude-integrated electroencephalogram at age 6 hours

Encephalopathy assessment

n

Abnormal aEEG n (%)

Sensitivity (95%CI)

Specificity (95%CI)

LR + (95%CI)

LR - (95%CI)

LR Test (Odds ratio) (95%CI)

Moderate-severe encephalopathy

Yes

42

35 (83)

97%

71%

3.2 a

0.06 a

55.22 a

No

18

1 (6)

(86 – 100)

(49 – 87)

(1.75 – 5.84)

(0.01 – 0.28)

(8.73 – 349.15)

Thompson score ≥ 7

Yes

44

36 (82)

100%

67%

2.9 a

0.02 a

141.71 a

 

No

16

0 (0)

(90 – 100)

(45 – 84)

(1.7 – 5)

(0 – 0.33)

(7.71 – 2603.42)

  1. LR: Likelihood ratio, aEEG: amplitude-integrated EEG,
  2. a : When zero count cells are present, LR is estimated using a substitution formula: 0.5 is added to all cell frequencies before calculation.