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Table 3 Association of DRD4 exon III variable number of tandems repeat genotypes to baseline parameters and outcomes of a weight loss intervention in 451 overweight/obese children

From: Association analyses for dopamine receptor gene polymorphisms and weight status in a longitudinal analysis in obese children before and after lifestyle intervention

  No 7R + alleles One 7R + allele Two 7R + alleles Additivea Recessive Dominant
N 285 148 18    
Baseline BMI b 27.25 ± 4.39 27.41 ± 4.58 28.97 ± 3.81 0.279 0.355 0.456
Change in BMI b,d -0.48 ± 1.95 -0.62 ± 2.00 -1.01 ± 2.42 0.479 0.434 0.362
Baseline BMI SDS c 2.34 ± 0.48 2.38 ± 0.53 2.5 ± 0.3 0.413 0.336 0.253
Change in BMI SDS c,d -0.25 ± 0.32 -0.32 ± 0.36 -0.30 ± 0.43 0.358 0.746 0.152
Baseline triceps skinfold (mm) b,e 31.17 ± 9.45 30.63 ± 7.08 34.82 ± 5.11 0.167 0.107 0.825
Change in triceps skinfold (mm) b,e -2.94 ± 11.29 -3.03 ± 6.45 -4.03 ± 6.71 0.915 0.867 0.976
Baseline subscapular skinfold (mm) b,e 29.95 ± 10.58 29.31 ± 8.29 32.45 ± 5.56 0.440 0.344 0.776
Change in subscapular skinfold (mm) b,e -2.73 ± 11.09 -2.04 ± 9.15 -3.27 ± 9.74 0.805 0.935 0.573
  1. All values are mean ± SD. aAdditive (overall) p-value for the model comparing 0, 1, or >1 repeats.
  2. bLinear Regression P-value adjusted for age, puberty and gender. cUnadjusted linear regression P-value. dMissing values 1-4%; eMissing values 5-20%.