Association analyses for dopamine receptor gene polymorphisms and weight status in a longitudinal analysis in obese children before and after lifestyle intervention

Table 3 Association of DRD4 exon III variable number of tandems repeat genotypes to baseline parameters and outcomes of a weight loss intervention in 451 overweight/obese children

	No 7R + alleles	One 7R + allele	Two 7R + alleles	Additive^a	Recessive	Dominant
N	285	148	18
Baseline BMI ^b	27.25 ± 4.39	27.41 ± 4.58	28.97 ± 3.81	0.279	0.355	0.456
Change in BMI ^b,d	-0.48 ± 1.95	-0.62 ± 2.00	-1.01 ± 2.42	0.479	0.434	0.362
Baseline BMI SDS ^c	2.34 ± 0.48	2.38 ± 0.53	2.5 ± 0.3	0.413	0.336	0.253
Change in BMI SDS ^c,d	-0.25 ± 0.32	-0.32 ± 0.36	-0.30 ± 0.43	0.358	0.746	0.152
Baseline triceps skinfold (mm) ^b,e	31.17 ± 9.45	30.63 ± 7.08	34.82 ± 5.11	0.167	0.107	0.825
Change in triceps skinfold (mm) ^b,e	-2.94 ± 11.29	-3.03 ± 6.45	-4.03 ± 6.71	0.915	0.867	0.976
Baseline subscapular skinfold (mm) ^b,e	29.95 ± 10.58	29.31 ± 8.29	32.45 ± 5.56	0.440	0.344	0.776
Change in subscapular skinfold (mm) ^b,e	-2.73 ± 11.09	-2.04 ± 9.15	-3.27 ± 9.74	0.805	0.935	0.573

All values are mean ± SD. ^aAdditive (overall) p-value for the model comparing 0, 1, or >1 repeats.
^bLinear Regression P-value adjusted for age, puberty and gender. ^cUnadjusted linear regression P-value. ^dMissing values 1-4%; ^eMissing values 5-20%.

ISSN: 1471-2431