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Table 1 Association of DRD2/ANKK1 rs1800497 genotypes to baseline parameters and outcomes of a weight loss intervention among overweight/obese children (N = 451)

From: Association analyses for dopamine receptor gene polymorphisms and weight status in a longitudinal analysis in obese children before and after lifestyle intervention

  CC (A2/A2) CT (A1/A2) TT (A1/ A1) CC&CT Additivea Recessive (T) Dominant (T)
N 308 132 11 440    
Baseline BMI b 27.45 ± 4.49 27.19 ± 4.42 26.49 ± 2.45 27.38 ± 4.46 0.686 0.197 0.561
Change in BMI b,e -0.41 ± 1.95 -0.99 ± 1.93 0.75 ± 2.51 -0.58 ± 1.96 0.002 0.023 0.024
Baseline BMI-SDS c 2.37 ± 0.50 2.35 ± 0.48 2.13 ± 0.38 2.36 ± 0.50 0.285 0.125 0.460
Change in BMI-SDS c,e -0.26 ± 0.34 -0.34 ± 0.33 -0.08 ± 0.36 -0.28 ± 0.34 0.015 0.060 0.090
Baseline triceps skinfold (mm) b,d 31.29 ± 8.80 31.28 ± 11.22 32.05 ± 6.25 31.29 ± 9.55 0.966 0.932 0.850
Change in triceps skinfold (mm) b,d -2.40 ± 10.41 -5.38 ± 11.59 -1.86 ± 6.47 -3.27 ± 10.83 0.053 0.639 0.027
Baseline subscapular skinfold (mm) b,d 30.12 ± 9.75 29.53 ± 11.38 30.82 ± 5.95 29.95 ± 10.25 0.837 0.873 0.741
Change in subscapular skinfold (mm) b,d -2.71 ± 11.05 -3.24 ± 10.67 2.91 ± 7.67 -2.87 ± 10.92 0.204 0.086 0.952
  1. All values are mean ± SD. After adjustment for multiple comparisons P-values <0.025 were considered as significant (in bold letters). aAdditive (overall) p-value for the model comparing CC, CT, TT.
  2. bLinear Regression P-value adjusted for age, puberty and gender. cUnadjusted linear regression P-value. dMissing values 1-4%; eMissing values 5-22%.