Table 5 Adverse effects of iron supplementation in low birth weight infants
From: Benefits of Iron supplementation for low birth weight infants: A systematic review
Study | Oxidative stress | Inhibition of Other Nutrient Absorption | Neonatal Morbidity | Blood Transfusion | Other Adverse Effects |
|---|---|---|---|---|---|
Hall et al. 1993[25] | NA | NA | NA | NA | No adverse effects in infants who received higher iron intake |
Franz et al. 2000[27] | NA | NA | NA | NA | No adverse effects once enteral feeding (100 mL/ kg/d) tolerated |
Friel et al. 2001[28] | No differences in MDA, SOD, CAT between the high and normal groups; GHSPx slightly higher in the high group | PLCU and PLZN significantly lower in high group | Prevalence of respiratory infection greater in the high group | NA | NA |
Miller et al. 2006[30] | No differences in blood or urine isoprostanes | NA | NA | No difference | NA |
Arnon et al. 2007[31] | NA | NA | No difference | More transfusions in the 4 wk group vs the 2 wk group (10/ 36 vs 1/32) | NA |
Braekke et al. 2007[33] | No significant changes in urine isoprostane, 2,3-dinor, total hydroperoxides; plasma antioxidants were largely unchanged | NA | NA | NA | NA |
Aggarwal et al. 2005[29] | NA | NA | Prevalence of respiratory infection or bronchiolitis slightly higher in T vs C group (10/32 vs 3/30) | NA | 2 infants in the T group reported mild vomiting |
Sankar et al. 2009[34] | NA | NA | No difference (19 vs 22 % for T and C groups) | No difference (10 vs 13 for T and C groups) | NA |
Berglund et al. 2010[35] | NA | NA | No difference | NA | NA |