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Table 5 Adverse effects of iron supplementation in low birth weight infants

From: Benefits of Iron supplementation for low birth weight infants: A systematic review

Study Oxidative stress Inhibition of Other Nutrient Absorption Neonatal Morbidity Blood Transfusion Other Adverse Effects
Hall et al. 1993[25] NA NA NA NA No adverse effects in infants who received higher iron intake
Franz et al. 2000[27] NA NA NA NA No adverse effects once enteral feeding (100 mL/ kg/d) tolerated
Friel et al. 2001[28] No differences in MDA, SOD, CAT between the high and normal groups; GHSPx slightly higher in the high group PLCU and PLZN significantly lower in high group Prevalence of respiratory infection greater in the high group NA NA
Miller et al. 2006[30] No differences in blood or urine isoprostanes NA NA No difference NA
Arnon et al. 2007[31] NA NA No difference More transfusions in the 4 wk group vs the 2 wk group (10/ 36 vs 1/32) NA
Braekke et al. 2007[33] No significant changes in urine isoprostane, 2,3-dinor, total hydroperoxides; plasma antioxidants were largely unchanged NA NA NA NA
Aggarwal et al. 2005[29] NA NA Prevalence of respiratory infection or bronchiolitis slightly higher in T vs C group (10/32 vs 3/30) NA 2 infants in the T group reported mild vomiting
Sankar et al. 2009[34] NA NA No difference (19 vs 22 % for T and C groups) No difference (10 vs 13 for T and C groups) NA
Berglund et al. 2010[35] NA NA No difference NA NA
  1. C, control; CAT, catalase; GHSPx, glutathione peroxidase; MDA, malondialdehyde; PLCU, plasma copper; PLZN, plasma zinc; T, iron supplementation group; SOD, superoxide dismutase; NA, not available.