Table 1 Genotype and allele frequencies of -844 and HindIII PAI-1 polymorphisms in cases and controls
Polymorphism | Metabolic syndrome % (n= 48) | Metabolically healthy % (n = 52) | P value* | OR CI (95%); Pvalue |
|---|---|---|---|---|
-844 G/A PAI-1 | ||||
Genotype | ||||
G/G § | 40 (19) | 65 (34) | 0.034 | 1.0 |
G/A | 52 (25) | 31 (16) | 2.8 (1.11-7.08); 0.015 | |
A/A | 8 (4) | 4 (2) | 3.6 (0.45-42.06); 0.15 | |
Allele | ||||
G | 66 (63) | 81 (84) | 0.015 | 1.0 |
A | 34 (33) | 19 (20) | 2.2 (1.10-4.43); 0.015 | |
Genetic model | ||||
Do | ||||
G/G § | 40 (19) | 65 (34) | 0.01 | 1.0 |
G/A + A/A | 60 (29) | 35 (18) | 2.9 (1.18-7.05); 0.009 | |
HindIII C/G PAI-1 | ||||
Genotype | ||||
C/C § | 50 (24) | 63 (33) | 0.28 | 1.0 |
C/G | 44 (21) | 35 (18) | 1.6 (0.65-3.95); 0.25 | |
G/G | 6 (3) | 2 (1) | 4.12 (0.30-222.9); 0.22 | |
Allele | ||||
C | 72 (69) | 81 (84) | 0.13 | 1.0 |
G | 28 (27) | 19 (20) | 1.64 (0.8-3.36); 0.13 | |
Genetic model | ||||
Do | ||||
C/C § | 50 (24) | 63 (33) | 0.17 | 1.0 |
C/G + G/G | 50 (24) | 37 (19) | 1.73 (0.75-4.17); 0.13 |