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Table 3 Multivariable analysis in CCS of sedentary lifestyle (obesity and low lean body mass) and hormones influenced by adiposity (IL-6 and adiponectin) associated with BMD Z-score ≤ -1

From: Modifiable risk factors associated with bone deficits in childhood cancer survivors

Outcome: Lumbar spine BMD Z-score ≤ -1

 

Categories

OddsRatio

95%CI

P

Age at Study

1 year increase

2.2

1.7-3.0

< 0.001

Ethnicity

Other

1.0

-

-

 

White non-Hispanic

2.6

0.9-9.1

0.104

Tanner, 1-5

One stage increase

0.4

0.2-0.7

< 0.001

Sex

Female

1.0

-

-

 

Male

1.6

0.7-3.4

0.270

Lean Body Mass

> 35 kg

1.0

-

-

 

≤ 35 kg

4.1

1.8-9.6

< 0.001

Percent Body Fat

1% increase

0.97

0.94-1.0

0.088

Physical Activity Score

One unit increase

0.99

0.99-1.0

0.042

  1. Years since diagnosis, IL-6, adiponectin, and screen time were not significant factors (p-value > 0.1) and were therefore removed from the model