Table 2 Multivariable analysis in CCS of sedentary lifestyle (obesity and low lean body mass) and hormones influenced by adiposity (IL-6 and adiponectin) associated with BMD Z-score ≤ -1

Age at study

≤ 16 years

1.0

-

-

> 16 years

2.5

0.8-8.1

0.125

Ethnicity

Other

1.0

-

-

White non-Hispanic

1.7

0.5-6.9

0.420

Tanner stage, 1-5

One stage increase

2.2

1.3-3.8

0.006

Sex

Female

1.0

-

-

Male

2.6

0.8-10.0

0.137

Percent Body Fat

1% increase

0.95

0.9-1.0

0.070

Lean Body Mass

1 kg increase

0.85

0.8-0.9

< 0.001

Years Since Diagnosis

5-9 years

1.0

-

-

> 9.0 years

2.3

0.9-6.3

0.080

IL-6

≤ 2.5 ng/dl

1.0

-

-

> 2.5 ng/dl

4.4

1.5-12.9

0.007

Screen time*, per day

0-1 hours

1.0

-

-

≥ 2 hours

4.1

1.3-18.6

0.033