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Table 3 Outcome prediction at birth: uni- and multivariate association of clinical and demographic parameters known at birth with mortality, adverse outcome and unfavourable outcome

From: Outcome at two years of age in a Swiss national cohort of extremely preterm infants born between 2000 and 2008

MORTALITY Univariate model†   Multivariate model‡  
  OR (95%-CI) p-value OR (95%-CI) p-value
Gestational age (weeks) 0.39 (0.34 - 0.44) <0.001 0.40 (0.35 - 0.47) <0.001
BW z-score 0.64 (0.56 - 0.74) <0.001 NA  
BW z-score < −2 6.99 (3.09 - 15.85) <0.001 11.68 (4.73 - 28.86) <0.001
BW z-score −2 to −1 2.10 (1.46 - 3.03) <0.001 2.71 (11.78 - 4.12) <0.001
Male sex 1.06 (0.82 - 1.35) 0.67 1.15 (0.86 - 1.54) 0.33
Outborn 0.80 (0.45 - 1.45) 0.47 NA  
Antenatal corticosteroids 0.34 (0.26 - 0.44) <0.001 0.46 (0.34 - 0.62) <0.001
Caesarean delivery 0.49 (0.37 - 0.65) <0.001 NA  
Multiple pregnancy 1.02 (0.77 - 1.34) 0.90 1.27 (0.91 - 1.78) 0.16
ADVERSE OUTCOME Univariate model†   Multivariate model‡  
  OR (95%-CI) p-value OR (95%-CI) p-value
Gestational age (weeks) 0.47 (0.41 - 0.53) <0.001 0.49 (0.42 - 0.56) <0.001
BW z-score 0.71 (0.62 - 0.88) <0.001 NA  
BW z-score < −2 5.36 (2.22 - 12.90) <0.001 7.90 (3.08 - 20.25) <0.001
BW z-score −2 to −1 1.91 (1.32 - 2.78) <0.001 2.35 (1.59 - 3.55) <0.001
Male sex 1.20 (0.94 - 1.54) 0.15 1.34 (1.01 - 1.77) 0.042
Outborn 0.98 (0.53 - 1.81) 0.95 NA  
Antenatal corticosteroids 0.40 (0.31 - 0.53) <0.001 0.51 (0.38 - 0.69) <0.001
Caesarean delivery 0.53 (0.39 - 0.70) <0.001 NA  
Multiple pregnancy 0.96 (0.73 - 1.27) 0.80 1.19 (0.87 - 1.64) 0.28
UNFAVOURABLE OUTCOME Univariate model†   Multivariate model‡  
  OR (95%-CI) p-value OR (95%-CI) p-value
Gestational age (weeks) 0.52 (0.45 - 0.59) <0.001 0.54 (0.47 - 0.61) <0.001
BW z-score 0.73 (0.63 - 0.85) <0.001 NA  
BW z-score < −2 12.05 (2.82 - 51.48) <0.001 16.91 (3.84 - 74.47) <0.001
BW z-score −2 to −1 1.59 (1.08 - 2.33) 0.019 1.82 (1.20 - 2.74) 0.004
Male sex 1.24 (0.96 - 1.59) 0.09 1.35 (1.02 - 1.77) 0.033
Outborn 1.30 (0.68 - 2.49) 0.42 NA  
Antenatal corticosteroids 0.48 (0.36 - 0.63) <0.001 0.57 (0.43 - 0.77) <0.001
Caesarean delivery 0.69 (0.51 - 0.93) <0.001 NA  
Multiple pregnancy 1.05 (0.79 - 1.38) 0.76 1.31 (0.96 - 1.78) 0.087
  1. The table gives all parameters that showed an unequal distribution among groups as shown in Table I or that are known from previous publications to act as confounders. † The univariate model is adjusted for study centre and year group. ‡ The multivariate model contains all parameters that were associated with the outcome in the univariate model.
  2. CI, confidence interval; OR, Odd’s ratio; BW, birth weight.
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BMC Pediatrics

ISSN: 1471-2431

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