MORTALITY
|
Univariate model†
| |
Multivariate model‡
| |
---|
|
OR (95%-CI)
|
p-value
|
OR (95%-CI)
|
p-value
|
---|
Gestational age (weeks)
|
0.39 (0.34 - 0.44)
|
<0.001
|
0.40 (0.35 - 0.47)
|
<0.001
|
BW z-score
|
0.64 (0.56 - 0.74)
|
<0.001
|
NA
| |
BW z-score < −2
|
6.99 (3.09 - 15.85)
|
<0.001
|
11.68 (4.73 - 28.86)
|
<0.001
|
BW z-score −2 to −1
|
2.10 (1.46 - 3.03)
|
<0.001
|
2.71 (11.78 - 4.12)
|
<0.001
|
Male sex
|
1.06 (0.82 - 1.35)
|
0.67
|
1.15 (0.86 - 1.54)
|
0.33
|
Outborn
|
0.80 (0.45 - 1.45)
|
0.47
|
NA
| |
Antenatal corticosteroids
|
0.34 (0.26 - 0.44)
|
<0.001
|
0.46 (0.34 - 0.62)
|
<0.001
|
Caesarean delivery
|
0.49 (0.37 - 0.65)
|
<0.001
|
NA
| |
Multiple pregnancy
|
1.02 (0.77 - 1.34)
|
0.90
|
1.27 (0.91 - 1.78)
|
0.16
|
ADVERSE OUTCOME
|
Univariate model†
| |
Multivariate model‡
| |
|
OR
(95%-CI)
|
p-value
|
OR
(95%-CI)
|
p-value
|
Gestational age (weeks)
|
0.47 (0.41 - 0.53)
|
<0.001
|
0.49 (0.42 - 0.56)
|
<0.001
|
BW z-score
|
0.71 (0.62 - 0.88)
|
<0.001
|
NA
| |
BW z-score < −2
|
5.36 (2.22 - 12.90)
|
<0.001
|
7.90 (3.08 - 20.25)
|
<0.001
|
BW z-score −2 to −1
|
1.91 (1.32 - 2.78)
|
<0.001
|
2.35 (1.59 - 3.55)
|
<0.001
|
Male sex
|
1.20 (0.94 - 1.54)
|
0.15
|
1.34 (1.01 - 1.77)
|
0.042
|
Outborn
|
0.98 (0.53 - 1.81)
|
0.95
|
NA
| |
Antenatal corticosteroids
|
0.40 (0.31 - 0.53)
|
<0.001
|
0.51 (0.38 - 0.69)
|
<0.001
|
Caesarean delivery
|
0.53 (0.39 - 0.70)
|
<0.001
|
NA
| |
Multiple pregnancy
|
0.96 (0.73 - 1.27)
|
0.80
|
1.19 (0.87 - 1.64)
|
0.28
|
UNFAVOURABLE OUTCOME
|
Univariate model†
| |
Multivariate model‡
| |
|
OR
(95%-CI)
|
p-value
|
OR
(95%-CI)
|
p-value
|
Gestational age (weeks)
|
0.52 (0.45 - 0.59)
|
<0.001
|
0.54 (0.47 - 0.61)
|
<0.001
|
BW z-score
|
0.73 (0.63 - 0.85)
|
<0.001
|
NA
| |
BW z-score < −2
|
12.05 (2.82 - 51.48)
|
<0.001
|
16.91 (3.84 - 74.47)
|
<0.001
|
BW z-score −2 to −1
|
1.59 (1.08 - 2.33)
|
0.019
|
1.82 (1.20 - 2.74)
|
0.004
|
Male sex
|
1.24 (0.96 - 1.59)
|
0.09
|
1.35 (1.02 - 1.77)
|
0.033
|
Outborn
|
1.30 (0.68 - 2.49)
|
0.42
|
NA
| |
Antenatal corticosteroids
|
0.48 (0.36 - 0.63)
|
<0.001
|
0.57 (0.43 - 0.77)
|
<0.001
|
Caesarean delivery
|
0.69 (0.51 - 0.93)
|
<0.001
|
NA
| |
Multiple pregnancy
|
1.05 (0.79 - 1.38)
|
0.76
|
1.31 (0.96 - 1.78)
|
0.087
|
- The table gives all parameters that showed an unequal distribution among groups as shown in Table I or that are known from previous publications to act as confounders. † The univariate model is adjusted for study centre and year group. ‡ The multivariate model contains all parameters that were associated with the outcome in the univariate model.
- CI, confidence interval; OR, Odd’s ratio; BW, birth weight.