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Table 2 Early infectious episodes and association with celiac disease

From: Early infections are associated with increased risk for celiac disease: an incident case-referent study

  Descriptive   
Exposuresa Cases Referents Bivariate analyses Multivariate analyses P-value d
[n=373] [n=581] OR (95% CI)b OR (95% CI)c  
  n (%) n (%)    
Number of infectious episode(s)      
 0-2 241 (65) 422 (73) 1.0 1.0  
 ≥3 132 (35) 159 (27) 1.5 (1.1-2.0) 1.5 (1.1-2.0) e 0.014
Infectious episode(s) excluding gastroenteritis      
 0-2 250 (67) 429 (74) 1.0 1.0  
 ≥3 123 (33) 152 (26) 1.5 (1.1-2.0) 1.4 (1.0-1.9) 0.035
Gastroenterits      
 0 344 (92) 554 (95) 1.0 1.0  
 ≥1 29 (8) 27 (5) 1.8 (1.0-3.2) 1.8 (0.99-3.3) 0.053
  1. a Infectious episodes before six months of age.
  2. b Bivariate conditional logistic regression using matched sets of cases with 1–2 referents.
  3. c Multivariate conditional logistic regression using matched sets of cases with 1–2 referents, with each exposure adjusted separately for infant feeding and socioeconomic status (compare Table 1).
  4. d Corresponding P-value for the multivariate analyses.
  5. e Preliminary version of this result has previously been included in review articles/book chapters [2227].