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Table 1 Rates of lymphocyte respiration, thyroid function and clinical findings in trisomy 21 children

From: Lymphocyte respiration in children with Trisomy 21

Children No.

Age (yr)

Gender

BMI (kg/m2)

k c (μM O2 min-1 per 107 cells)

TSH (mIU/L)

Free T4 (pmol/L)

Clinical status

1

1.5

F

12.8

1.6

3.5

20.7

AVSD

2

5

M

16.1

2.0

1.6

14.7

celiac disease

3

17

M

28.6

1.2

4.9

9.5

normal

4

12

M

16.3

0.6

2.6

10

AVSD

5

12

F

30.8

1.2

3.8

13.2

VSD

6

9

M

17.1

0.6

2.6

NA

bronchial asthma

7*

15

M

30.2

0.6

2.8

10.0

aortic stenosis, hypothyroidism

8

15

M

44.3

2.8

13.2

11.0

Moya Moya disease, hypothyroidism

9

3

F

13.8

0.4

3.7

14.2

bronchial asthma

10

2

F

15.2

0.6

5.3

13.0

obstructive sleep apnea, low vitamin D

11

3

M

14.5

0.5

2.9

15.8

ASD, PDA

12

5

M

17.5

0.9

2.6

9.9

VSD

13*

4

M

15.7

0.2

12.6

11.6

hypothyroidism

14

10

F

NA

0.8

5.1

10.4

normal

15

6

M

18.7

0.4

5.1

10.5

normal

16

4

M

14.8

1.2

3.6

11.9

normal

17

9

F

16

0.7

3.9

10.7

normal

18

1.5

M

16.3

1.5

11.6

11.9

hypothyroidism

19

5

M

NA

1.0

2.9

11.1

normal

20

6

M

20.7

0.3

3.9

10.4

normal

21

8

M

31.4

0.4

5.1

10.5

asthma, myelomeningocele

22

2

F

14.3

0.3

7.7

11.2

normal

23

7

F

17.8

0.3

1.3

9.3

normal

24

8

F

23.2

0.2

3.7

11.3

AVSD

25

6

M

35.1

0.2

3.6

14.1

AVSD

26

4

M

13.6

0.7

6.4

14.1

normal

mean ± SD (CV)

6.9 ± 4.4

 

20.6 ± 8.3 (40%)

0.82 ± 0.62 (76%)

4.8 ± 3.1

12.0 ± 2.5

 
  1. AVSD, atrioventricular septal defect; VSD, ventricular septal defect; ASD, atrial septal defect; PDA, patent ductus arteriosus; CV, coefficient of variation. NA, not available.
  2. In normal 2 to7 year-old children, the TSH values are 0.10 to 5.9 mU/L (mean = 2.2 mU/L); in normal 9 to 16 year-old children, the TSH values are 0.20 to 6.1 mU/L (mean = 2.3 mU/L).
  3. Reference ranges for free T4 are 11.0 to 22.6 pmol/L in children 1 to 5 years of age, 11.6 to 21.5 pmol/L in children 6 to 10 years of age, and 12.0 to 20.6 pmol/L in children 11 to 19 years of age (https://www.labcorp.com/wps/portal/provider).
  4. * On thyroxin prior to O2 consumption testing.