Figure 3
Lymphocyte respiration in children with trisomy 21 as a function of serum TSH. Panel a: Circles, children (n = 21) with trisomy 21 and normal TSH (levels ≤5.3 mU/L; line is the best linear fit, R 2 > 0.0727); diamonds, children (n = 5) with trisomy 21 and elevated TSH (levels 7.7 to 13.2 mU/L). Panel b: Children (n = 14) with trisomy 21 and abnormal (low) rate of respiration (k c < 0.60 μM O2 per min per 107 cells). The horizontal line reflects upper limit of normal TSH (<6.1 mU/L, please see footnote to Table 1).