Skip to main content

Table 1 Clinical and laboratory parameters of jaundiced males infants with (n = 32) and without G6PD deficiency (n = 184). G6PD variants were analyzed for G6PD deficient infants only (n = 32)

From: Neonatal Hyperbilirubinemia in infants with G6PD c.563C > T Variant

Variables G6PD normal G6PD deficient G6PD Variants   P-value
    c.563C > T c.131C > G Unknown  
n 184 32 21 3 8  
Weight (kg) 2.7 ± 0.7 2.9 ± 0.6 2.9 ± 0.5 2.6 ± 0.8 2.8 ± 1.0 0.157
Age at presentation (days) 2.2 ± 2.2 1.6 ± 1.3* 1.6 ± 1.4 1.6 ± 0.6 1.5 ± 1.1 0.215
Icterus in first 24 h of life n (%) 63(33.7) 15(46.9) 10(47.6) 1(33) 4(50) <0.001**
Hemoglobin (g/dl) 16.5 ± 2.5 15.5 ± 1.9* 15.7 ± 2.09 13.9 ± 0.32 15.7 ± 1.8 0.172
Retic count (%) 4.0 ± 2.2 5.0 ± 2.5* 4.9 ± 2.5 5.1 ± 0.8 5.0 ± 3.2 0.140
G6PD activity (U/gHb) 14.0 ± 4.5 0.6 ± 0.9* 0.3 ± 0.2 2.2 ± 2.2 1.6 ± 2.3 <0.001**
TSH (μIU/ml) 5.9 ± 4.7 6.9 ± 4.5 7.0 ± 4.3 12.2 ± 9.2 5.1 ± 3.2 0.355
Peak bilirubin (mg/dl) 13.8 ± 4.6 16.7 ± 6.0* 16.8 ± 5.4 14.9 ± 1.2 17.2 ± 8.8 0.008**
Age at peak bilirubin (days) 4.3 ± 2.3 2.6 ± 1.9* 2.9 ± 1.6 1.6 ± 1.5 2.6 ± 2.7 0.007**
Frequency of Phototherapy (n/%) 154/82 29/90 18/86 3/100 8/100 0.701
Frequency of blood exchange (n/%) 28/15 4/12 3/14 0/0 1/13 0.934
Hospital stay (days) 6.2 ± 4.1 5.6 ± 3.1 5.2 ± 3.1 4.6 ± 1.5 7.1 ± 3.5 0.254
  1. All values are expressed as mean ± 1SD.
  2. *p < 0.05 between G6PD normal and deficient neonates** P-value < 0.05 between G6PD c.563C > T variant group and G6PD normal infants.