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Table 1 Clinical and laboratory parameters of jaundiced males infants with (n = 32) and without G6PD deficiency (n = 184). G6PD variants were analyzed for G6PD deficient infants only (n = 32)

From: Neonatal Hyperbilirubinemia in infants with G6PD c.563C > T Variant

Variables

G6PD normal

G6PD deficient

G6PD Variants

 

P-value

   

c.563C > T

c.131C > G

Unknown

 

n

184

32

21

3

8

 

Weight (kg)

2.7 ± 0.7

2.9 ± 0.6

2.9 ± 0.5

2.6 ± 0.8

2.8 ± 1.0

0.157

Age at presentation (days)

2.2 ± 2.2

1.6 ± 1.3*

1.6 ± 1.4

1.6 ± 0.6

1.5 ± 1.1

0.215

Icterus in first 24 h of life n (%)

63(33.7)

15(46.9)

10(47.6)

1(33)

4(50)

<0.001**

Hemoglobin (g/dl)

16.5 ± 2.5

15.5 ± 1.9*

15.7 ± 2.09

13.9 ± 0.32

15.7 ± 1.8

0.172

Retic count (%)

4.0 ± 2.2

5.0 ± 2.5*

4.9 ± 2.5

5.1 ± 0.8

5.0 ± 3.2

0.140

G6PD activity (U/gHb)

14.0 ± 4.5

0.6 ± 0.9*

0.3 ± 0.2

2.2 ± 2.2

1.6 ± 2.3

<0.001**

TSH (μIU/ml)

5.9 ± 4.7

6.9 ± 4.5

7.0 ± 4.3

12.2 ± 9.2

5.1 ± 3.2

0.355

Peak bilirubin (mg/dl)

13.8 ± 4.6

16.7 ± 6.0*

16.8 ± 5.4

14.9 ± 1.2

17.2 ± 8.8

0.008**

Age at peak bilirubin (days)

4.3 ± 2.3

2.6 ± 1.9*

2.9 ± 1.6

1.6 ± 1.5

2.6 ± 2.7

0.007**

Frequency of Phototherapy (n/%)

154/82

29/90

18/86

3/100

8/100

0.701

Frequency of blood exchange (n/%)

28/15

4/12

3/14

0/0

1/13

0.934

Hospital stay (days)

6.2 ± 4.1

5.6 ± 3.1

5.2 ± 3.1

4.6 ± 1.5

7.1 ± 3.5

0.254

  1. All values are expressed as mean ± 1SD.
  2. *p < 0.05 between G6PD normal and deficient neonates** P-value < 0.05 between G6PD c.563C > T variant group and G6PD normal infants.