Table 3 Clinical blood glucose control variables during trials and comparison with retrospective control

Number of episodes

8

22

21

Total hours

226 hours

3168 hours

3571 hours

Number of BG measurements

117

1003

1091

BG sampling site: arterial/capillary

100%/0%

27%/73%

45%/55%

BG median [IQR] (mmol/L)

7.4 [6.2 - 9.4]

6.6 [5.5 - 8.2]

8.0 [6.6 - 9.4]

% BG within 4.0 - 7.0 mmol/L

40.9

53.7

29.5

% BG within 4.0 - 8.0 mmol/L

63.9

68.4

48.4

% BG > 10 mmol/L

22.6

11.7

19.2

% BG < 4.0 mmol/L

0.9

4.0

2.7

% BG < 3.0 mmol/L

0.0

0.5

0.4

% BG < 2.7 mmol/L

0.00

0.25

0.25

Median insulin rate [IQR] (U/kg/hr)

0.058 [0.038 - 0.107]

0.033 [0.028 - 0.040]

0.025 [0.010 - 0.045]

Median glucose rate [IQR] (mg/kg/min)

8.2 [7.1 - 9.4]

7.9 [6.1 – 9.3]

8.4 [6.3 - 9.1]

Per-patient statistics (presented as median [IQR])

Number of BG measurements

15.0 [13.0 - 17.5]

27.0 [15.0 - 44.8]

36.0 [21.0 - 54.0]

Initial BG (mmol/L)

11.4 [7.5 - 12.3]

11.4 [9.4 – 13.4]

8.9 [5.7 – 9.9]

Time between measurements (hours)

2.0 [2.0 - 2.1]

3.0 [2.8 - 3.3]

3.2 [2.6 - 4.0]

%BG within 4.0-7.0 mmol/L

41.4 [14.4 - 60.8]

60.4 [38.2 – 72.7]

29.6 [20.4 - 38.5]

%BG within 4.0-8.0 mmol/L

58.8 [48.3 - 75.9]

74.1 [57.7 - 84.2]

47.7 [42.9 - 55.7]

%BG < 4.0 mmol/L [IQR]

0.0 [0.0 - 0.0]

4.8 [3.1 - 9.3]

2.8 [0.0 - 5.4]

%BG < 3.0 mmol/L [IQR]

0.0 [0.0 - 0.0]

0.0 [0.0 - 2.0]

0.0 [0.0 - 0.2]

%BG < 2.7 mmol/L [IQR]

0.0 [0.0 - 0.0]

0.0 [0.0 - 0.7]

0.0 [0.0 - 0.0]

Dextrose rate (mg/kg/min)

1.2 [0.3 - 1.6]

5.2 [0.6 - 14.0]

4.8 [1.9 - 6.7]

EBM (mL/kg/day)

4.6 [1.0 - 5.7]

15.8 [2.3 - 41.9]

16.7 [5.4 – 27.2]

Patients that received EBM

6 (75%)

19 (86%)

18 (86%)

Proportion of dextrose via EBM (%)

1.2 [0.3 - 1.7]

11.0 [1.5 - 21.4]

5.5 [1.9 - 7.2]

Insulin rate (U/kg/hr)

0.058 [0.046 - 0.088]

0.033 [0.028 - 0.040]

0.025 [0.010 - 0.045]

Insulin sensitivity x 10^-3 (L/[mU.min])

1.28 [0.48 – 1.86]

1.73 [1.25 - 2.65]

1.93 [1.40 – 2.58]