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Table 3 Clinical blood glucose control variables during trials and comparison with retrospective control

From: Pilot study of a model-based approach to blood glucose control in very-low-birthweight neonates

Whole cohort statistics Short-term Long-term Retrospective
Number of episodes 8 22 21
Total hours 226 hours 3168 hours 3571 hours
Number of BG measurements 117 1003 1091
BG sampling site: arterial/capillary 100%/0% 27%/73% 45%/55%
BG median [IQR] (mmol/L) 7.4 [6.2 - 9.4] 6.6 [5.5 - 8.2] 8.0 [6.6 - 9.4]
% BG within 4.0 - 7.0 mmol/L 40.9 53.7 29.5
% BG within 4.0 - 8.0 mmol/L 63.9 68.4 48.4
% BG > 10 mmol/L 22.6 11.7 19.2
% BG < 4.0 mmol/L 0.9 4.0 2.7
% BG < 3.0 mmol/L 0.0 0.5 0.4
% BG < 2.7 mmol/L 0.00 0.25 0.25
Median insulin rate [IQR] (U/kg/hr) 0.058 [0.038 - 0.107] 0.033 [0.028 - 0.040] 0.025 [0.010 - 0.045]
Median glucose rate [IQR] (mg/kg/min) 8.2 [7.1 - 9.4] 7.9 [6.1 – 9.3] 8.4 [6.3 - 9.1]
Per-patient statistics (presented as median [IQR])
Number of BG measurements 15.0 [13.0 - 17.5] 27.0 [15.0 - 44.8] 36.0 [21.0 - 54.0]
Initial BG (mmol/L) 11.4 [7.5 - 12.3] 11.4 [9.4 – 13.4] 8.9 [5.7 – 9.9]
Time between measurements (hours) 2.0 [2.0 - 2.1] 3.0 [2.8 - 3.3] 3.2 [2.6 - 4.0]
%BG within 4.0-7.0 mmol/L 41.4 [14.4 - 60.8] 60.4 [38.2 – 72.7] 29.6 [20.4 - 38.5]
%BG within 4.0-8.0 mmol/L 58.8 [48.3 - 75.9] 74.1 [57.7 - 84.2] 47.7 [42.9 - 55.7]
%BG < 4.0 mmol/L [IQR] 0.0 [0.0 - 0.0] 4.8 [3.1 - 9.3] 2.8 [0.0 - 5.4]
%BG < 3.0 mmol/L [IQR] 0.0 [0.0 - 0.0] 0.0 [0.0 - 2.0] 0.0 [0.0 - 0.2]
%BG < 2.7 mmol/L [IQR] 0.0 [0.0 - 0.0] 0.0 [0.0 - 0.7] 0.0 [0.0 - 0.0]
Dextrose rate (mg/kg/min) 1.2 [0.3 - 1.6] 5.2 [0.6 - 14.0] 4.8 [1.9 - 6.7]
EBM (mL/kg/day) 4.6 [1.0 - 5.7] 15.8 [2.3 - 41.9] 16.7 [5.4 – 27.2]
Patients that received EBM 6 (75%) 19 (86%) 18 (86%)
Proportion of dextrose via EBM (%) 1.2 [0.3 - 1.7] 11.0 [1.5 - 21.4] 5.5 [1.9 - 7.2]
Insulin rate (U/kg/hr) 0.058 [0.046 - 0.088] 0.033 [0.028 - 0.040] 0.025 [0.010 - 0.045]
Insulin sensitivity x 10-3 (L/[mU.min]) 1.28 [0.48 – 1.86] 1.73 [1.25 - 2.65] 1.93 [1.40 – 2.58]
  1. Blood glucose (BG) results are resampled hourly.