BG concentration and estimated insulin sensitivity during short-term, long-term computerized insulin dosing trials and retrospective control. For the short-term trials each line in the top row of plots represents blood glucose concentration for each patient. The shaded region represents the 4–7 mmol/L target band. Each line in the bottom row of plots represents the evolution of sensitivity to exogenous insulin for each patient. For the long-term and retrospective patients summary boxplots are presented for each day of control.