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Table 1 Criteria used for case definition to identify cause-specific mortality*

From: Cause-specific neonatal mortality in a neonatal care unit in Northern Tanzania: a registry based cohort study

Causes of death

Case definition

Search criteria for clinical diagnosis in registry

Congenital malformation

lethal congenital malformation (congenital heart, spinal bifida, congenital syndromes, gastrointestinal malformation)

− multiple congenital malformation

− congenital heart disease

− spinal bifida/hydrocephalus

− congenital syndromes or syndrome baby and deaths due to systemic conditions such as-renal failure or gastrointestinal system

Birth asphyxia

birth asphyxia, hypoxic ischaemic encephalopathy Apgar based definition

− birth asphyxia weight >1000 g or gestational age >27 weeks

− birth asphyxia and prematurity with gestational age ≥33wks and birth weight ≥2500 g or birth weight ≥ 1800 g if gestational age unknown

− hypoxic ischaemic encephalopathy five minutes Apgar less than 7

Prematurity

prematurity, respiratory distress syndrome in preterm, necrotizing enterocolite in preterm birth

− prematurity

− prematurity and asphyxia with gestational age < 33 weeks and birth weight < 2500 g or birth weight < 1800 g if gestational age is unknown

− respiratory distress syndrome in preterm

− necrotizing enterocolitis

− birth asphyxia gestational age <27 weeks or birth weight <1000 g

− infection with gestational age <33 weeks

Infection

neonatal infection, sepsis/septicaemia, meningitis, pneumonia

− neonatal infection

− sepsis/septicaemia

− meningitis

− pneumonia

− impetigo neonatorum

Others

other specific causes not classified above

− neonatal jaundice

− meconium aspiration syndrome

− respiratory distress syndrome in term babies

  1. *The criterion was adapted from modified Wigglesworth classification and the revised decision tree [17, 18], and NICE classification [19] as used by Lawn et al. in classifying causes of neonatal deaths [20] with minor modifications.