Table 2 Multiple Sclerosis definition

Multiple Sclerosis (MS)

- Two or more non ADEM episodes of CNS demyelination separated in time (4 weeks) and space. For children aged > 10 years:

- Dissemination in space can be met if: MRI shows three of: 1) ≥ 9 white matter lesions or 1 gadolinium enhancing lesion, 2) ≥ 3 periventricular lesions, 3) One juxtacortical lesion, 4) an infratentorial lesion.

OR abnormal CSF (oligoclonal bands or elevated IgG index) with 2 lesions on the MRI (one in the brain).

- Dissemination in time can be met if: MRI shows new T2 or gadolinium enhancing lesions developing ≥ 3 months after initial event.