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Table 1 Sociodemographic and clinico-immunological characteristics at ART initiation by cohort, Arua, Uganda, 2006

From: Immunovirological response to combined antiretroviral therapy and drug resistance patterns in children: 1- and 2-year outcomes in rural Uganda

Patient characteristics

M12 cohort

M24 cohort

 

Eligible

(N = 70)

Surveyed

(N = 59)

Eligible

(N = 32)

Surveyed

(N = 27)

Demographic factors

    

   Girls (%)

32 (45)

28 (47.5)

14 (44)

11 (40.7)

   Median age, years [IQR]

5.4 [3.2 -8.2]

5.6 [3.2-8.3]

5.5 [4.2-7.7]

5.1 [4.2-7.5]

   Age group (%)

    

12-35 months

13 (18.6)

12 (20.3)

6 (18.8)

5 (18.5)

36-59 months

19 (27.1)

14 (23.7)

6 (18.8)

6 (22.2)

5-14 years

38 (54.3)

33 (55.9)

20 (62.4)

16 (59.3)

Treatment history

    

   ARV naïve (%)

67 (95.7)

56 (94.9)

31 (96.9)

26 (96.3)

   Median follow-up without ARVs, months [IQR]

5.9 [3.5-11.1]

6.9 [4.2-13.3]

6.3 [1.7-12.0]

6.4 [1.7-12.3]

Clinical factors

    

   Clinical stage (%)

n = 68

n = 58

n = 32

n = 27

Stage 1/2

16 (23.6)

13 (25.9)

7 (21.9)

5 (18.5)

Stage 3

44 (63.2)

36 (62.1)

18 (56.2)

15 (55.6)

Stage 4

9 (13.2)

7 (12.0)

7 (21.9)

7 (25.9)

   Weight-for-height z-score

n = 62

n = 52

n = 29

n = 25

Median [IQR]

-1.1

[-2.0 to -0.5]

-1.2

[-2.1 to -0.6]

-0.8

[-1.6 to -0.1]

-0.8

[-1.8 to -0.3]

< -2 score (%)

17 (27.4)

15 (28.8)

3 (10.3)

3 (12.0)

ART regimen (%)

    

   AZT 3TC NVP

54 (77.1)

49 (83.1)

25 (78.1)

21 (77.8)

   d4T 3TC NVP

16 (22.9)

10 (17.0)

7 (21.9)

6 (22.2)

CD4 testing, median [IQR]

    

   CD4 cell count a

n = 14

n = 11

n = 17

n = 15

 

190 [106-302]

200 [166-302]

70 [22-149]

70 [20-152]

   CD4% b

n = 12

n = 10

n = 2

n = 2

 

10 [8-14]

11 [8-14]

14 [10-17]

13 [10-17]

  1. Note: ART, antiretroviral therapy; 3TC, lamivudine; d4T, stavudine; NVP, nevirapine; AZT, zidovudine.
  2. a Number of children aged ≥ 5 years in M12 = 38 and in M24 = 20.
  3. b Number of children aged < 5 years in M12 = 32 and in M24 = 12.