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Table 1 Regional distribution of Fe3+ in brain of SIUD/SIDS victims and correlation with the alterations of the central nervous system and with the maternal smoking habit

From: Brain iron accumulation in unexplained fetal and infant death victims with smoker mothers-The possible involvement of maternal methemoglobinemia

Case no. Diagnosis Age at death BBB Iron positivity CNS structural alterations Maternal smoking
     Brainstem localization Cerebellum localization   Yes
1 SIUD 39 gw + ++
+
inferior olivary n
trigeminal n.
+ dentate n. arcuate n. hypoplasia
pre-Bötzinger n. hypoplasia
parafacial n. hypoplasia
No
2 SIUD 41 gw - + diffuse ++ subcortical parafacial n. hypoplasia Yes
3 SIUD 36 gw +++
-
+++
+
area postrema
tractus solitarius n
- - parafacial n. hypoplasia Yes
4 SIUD 32 gw + ++ diffuse - - arcuate n. hypoplasia
raphè n. hypoplasia
Yes
5 SIUD 40 gw ++ + superior olivary n ++
+++
Subcortical
dentate n.
parabrachial/Köllike-rFuse hypoplasia Yes
6 SIDS 4 m ++ ++ area postrema* ++ dentate n. cerebellar cortex immaturity Yes
7 SIDS 3 m - +++ basal pontine n* ++ diffuse pre-Bötzinger n. hypoplasia Yes
8 SIDS 7 m ++ +++ basal pontine n* +++
+++
subcortical
dentate n.
arcuate n. hypoplasia
raphè n. hypoplasia
inferior olivary n. hypoplasia
Yes
9 SIDS 6 m ++ ++ diffuse* +++
+++
subcortical
dentate n.
raphè n. hypoplasia Yes
10 SIDS 2 m - ++ diffuse ++ diffuse raphè n. hypoplasia
cerebellar cortex immaturity
Yes
11 SIDS 3 m ++ ++ diffuse + diffuse arcuate n. hypoplasia
raphè n. hypoplasia
Yes
12 SIDS 1 m - +
++
trigeminal n.
diffuse
++
++
subcortical
dentate n.
hypoglossal n. hypoplasia
raphè n. hypoplasia
Yes
  1. The intensities of iron deposition were: weak (+), strong (++), very strong (+++)
  2. gw = gestational weeks; m = postnatal months
  3. BBB = blood/brain barrier; n = nucleus
  4. * = presence of mitotic and/or multinucleated neurons.