Traditional and non-traditional treatments for autism spectrum disorder with seizures: an on-line survey

BMC Pediatrics

Table 7 Non-traditional treatment usage by seizure group.

Treatment	Overall	Controls	Clinical Seizures	Subclinical Seizures
Supplement treatments
Vitamin B12	24%	32%	20%^‡	26% ^ns,ns
L-Carnitine/Acetyl-L-Carnitine	21%	22%	18% ^ns	29% ^ns,ns
Magnesium	20%	26%	17% ^ns	22% ^ns,ns
Coenzyme Q10	14%	16%	12% ^ns	15% ^ns,ns
Glutathione	14%	14%	12% ^ns	18% ^ns,ns
Dimethylglycine	11%	14%	9% ^ns	13% ^ns,ns
Taurine	11%	10%	10% ^ns	14% ^ns,ns
GABA	9%	12%	8% ^ns	9% ^ns,ns
5-Hydroxytryptophan	8%	11%	6%^ns	9% ^ns,ns
L-Carnosine	6%	5%	5% ^ns	10%^ns,ns
Drug treatments
Chelation Therapy	12%	15%	10%^ns	16% ^ns,ns
Hyperbaric Oxygen Therapy	7%	6%	7% ^ns	10% ^ns,ns
Dietary treatments
Gluten Free Casein Free Diet	31%	41%	25% ^†	31%^ns,ns
Specific Carbohydrate Diet	6%	4%	6% ^ns	8% ^ns,ns
Atkins or Modified Atkins Diet	2%	1%	3% ^ns	2% ^ns,ns

‡p < = 0.001; †p < = 0.0001
For each treatment listed, statistical comparisons were made between the clinical seizure group and the control group (superscript after the clinical seizure percentage), the subclinical seizure group and the control group (1^st superscript after the subclinical seizure percentage) and between the clinical and subclinical seizure group (2^nd superscript after the subclinical seizure percentage). There are 15 treatments and 3 comparisons for each treatments resulting in 45 comparisons. The Bonferroni correction results in an alpha of 0.05/45 = 0.0011, so we have set the alpha to p < = 0.001 to be conservative.

ISSN: 1471-2431