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Table 11 Rates of specific adverse effects for the antiepileptic drug treatments reported to be most effective

From: Traditional and non-traditional treatments for autism spectrum disorder with seizures: an on-line survey

Adverse Effects Valproic Acid Lamotrigine Levetiracetam Ethosuximide
Mood Instability or Anger 10% 10% 21% 4%
Behavioral Change 5% 3% 8% 0%
Drowsiness/tiredness/fatigue 10% 4% 8% 7%
Change in appetite or weight 11% 2% 3% 7%
Increase in seizures 2% 5% 4% 7%
Constipation or diarrhea 3% 2% 1% 0%
Sleep disruption 4% 5% 3% 4%
Inattention or confusion 4% 3% 4% 0%
Rash or allergic reaction 1% 7% 1% 0%
Hyperactivity 4% 3% 3% 4%
Nausea and/or vomiting 2% 3% 1% 4%
Ataxia, tremor or dizziness 6% 3% 1% 0%
Unusual infection 1% 0% 1% 0%
Movement disorder 1% 2% 2% 0%
Anxiety 1% 1% 2% 0%
Headache 1% 3% 0% 0%
Hair loss 3% 1% 0% 0%
Visual disturbances 0% 1% 1% 0%
Speech disturbance 3% 4% 4% 0%
Enuresis 1% 0% 1% 0%
Other 6% 0% 2% 4%