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Table 3 Features of ovarian function after HCT

From: Inhibin B and anti-Müllerian hormone as markers of gonadal function after hematopoietic cell transplantation during childhood

Ovarian function

 

Normal

Abnormal

  

n (%)

n (%)

Patients

 

7 (21)

27 (79)

Age at HCT, yr

 

5.3 ± 1.2

7.4 ± 0.7

Age at evaluation, yr

 

14.7 ± 0.6

13.7 ± 0.3

Interval between HCT and evaluation, yr

 

9.4 ± 0.8

6.3 ± 0.7

Conditioning

   

TBI

 

3 (13)

21 (87)

TLI

 

1 (33)

2 (67)

Chemotheray alone

 

3 (43)

4 (57)

Cyclophosphamide

+

4 (18)

18 (82)

 

-

3 (25)

9 (75)

Busulfan

+

1 (12)

7 (88)

 

-

6 (23)

20 (77)

Melphalan

+

3 (30)

7 (70)

 

-

4 (17)

20 (83)

Inhibin B, pg/mL

 

87 ± 20

18.6 ± 4.3*

  

n = 7

 
   

Partial ovarian failure, n = 11

   

26.9 ± 10ª

   

Complete ovarian failure, n = 16

   

12.9 ± 1.1

AMH, pmol/L

 

0.7 ± 0.4

0.1 ± 0.1ª

  

n = 7

n = 18

  1. mean ± se
  2. a: NS
  3. P* = 0.0003 compared to normal ovarian function