Skip to main content

Table 2 Features of testis function after HCT

From: Inhibin B and anti-Müllerian hormone as markers of gonadal function after hematopoietic cell transplantation during childhood

FSH

Normal

Abnormal

 

n (%)

n (%)

Patients

10 (26)

28 (74)

Age at HCT, yr

8.6 ± 1.3

8.1 ± 0.6

Age at evaluation, yr

15.8 ± 0.5

16.7 ± 0.4

Interval between HCT and evaluation, yr

7.3 ± 1.5

8.6 ± 0.6

Conditioning

  

TBI

8 (23)

26 (77)

TLI

1 (33)

2 (67)

Chemotheray alone

1

 

Cyclophosphamide

+9 (45)

11 (55)

 

-1 (5)

17 (95)

Busulfan

+1 (100)

 
 

-9 (24)

28 (76)

Melphalan

+0

16 (100)

 

-10 (45)

12 (55)

Inhibin B, pg/mL

202 ± 58

35 ± 5*

 

n = 10

 
  

Tubular failure, n = 16

  

47 ± 7**

  

Tubular and Leydig cell failures, n = 12

  

20 ± 3

AMH, pmol/L

195 ± 86

41 ± 6***

 

n = 8

 
  

Tubular failure, n = 14

  

51 ± 7****

  

Tubular and Leydig cell failures, n = 9

  

24 ± 6

  1. mean±se
  2. P*<0.0001 compared to normal
  3. P**=0.01 compared to tubular and Leydig cell failures
  4. P***<0.005 compared to normal testis function
  5. P****<0.02 compared to tubular and Leydig cell failure