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Table 4 Receiver Operating Characteristic (ROC) curves of combinations of clinical findings with the greatest area under the curve (AUC), and sensitivity and specificity of various cut-off numbers of findings in predicting HIV-infection among exposed infants.

From: Utility of clinical parameters to identify HIV infection in infants below ten weeks of age in South Africa: a prospective cohort study

One of a combination of oral thrush, any lymphadenopathy, hepatomegaly, splenomegaly, plus:

ROC AUC

Findings present

Sensitivity (%)

Specificity (%)

A: weight < 15th centile, diaper dermatitis

0.754

1

77.9

61.2

  

2

47.7

88.0

  

3

25.2

98.4

B: weight < 50th centile, diaper dermatitis

0.717

1

88.9

29.6

  

2

48

90.4

  

3

20.6

99.2

C: weight < 3rd centile, reflux

0.744

1

63.8

80

  

2

31.4

97.6

  

3

12.5

100

One of a combination of oral thrush, diaper dermatitis, plus:

ROC AUC

Findings present

Sensitivity (%)

Specificity (%)

D: weight < 3rd centile

0.682

1

60.7

72

  

2

28.3

92.8

  

3

4.8

100

E: weight < 50th centile

0.666

1

84.7

30.4

  

2

46.8

82.4