Table 2 Frequency of selected physical findings and clinical events in very young HIV-infected with CD4% < 25% (severe immune suppression) versus CD4 ≥ 25%
|  | CD4 < 25% n = 62 | CD4 ≥ 25% n = 313 | Unadjusted p-value3 | AOR (95% CI)3 |
|---|---|---|---|---|
Female gender (%) | 29 (46.8) | 187 (59.7) | 0.06 | Â |
Median age, days (IQR) | 52 (42-66) | 45 (39-55) | 0.0021 | Â |
Anthropometry at screening | ||||
Median weight, kg (IQR) | 4.3 (3.9-5) | 4.4 (4.0-4.9) | 0.228 | 1.6 (1.1-2.4) |
Weight < 3 rd centile (%) | 19 (30.6) | 52 (16.6) | 0.010 | NA |
Weight < 15 th centile (%) | 36 (56.4) | 115 (37.0) | 0.004 | NA |
Weight < 50 th centile (%) | 51 (82) | 228 (72.8) | 0.121 | NA |
Median length, cm | 54 (52.5-55) | 54 (52-56) | 0.563 | 1.1 (0.98-1.2) |
Median HC, cm | 39 (38-40) | 39 (38-40) | 0.859 | 1.1 (0.9-1.1) |
Physical exam findings at screening | ||||
Any LAD # (%) | 33 (53.2) | 93 (29.7) | < 0.001 | 0.4 (0.2-0.7) |
Atopic dermatitis (%) | 14 (22.6) | 64 (20.4) | 0.705 | 1.1 (0.5-2.1) |
Diaper dermatitis | 28 (45.2) | 111 (35.5) | 0.149 | 0.7 (0.4-1.2) |
Oral thrush (%) | 29 (46.8) | 115 (36.7) | 0.138 | 0.7 (0.4-1.1) |
Hepatomegaly (%) | 11 (17.7) | 19 (6.1) | 0.002 | 0.4 (0.2-0.8) |
Splenomegaly (%) | 19 (30.6) | 51 (16.3) | 0.008 | 0.5 (0.3-0.9) |
Clinical event prior to or at screening | ||||
Gastroenteritis (%) | 12 (19.4) | 29 (9.3) | 0.020 | 0.5 (0.2-1.0) |
Otitis media (%) | 1 (1.6) | 5 (1.6) | 0.993 | 1.5 (0.2-13.8) |
Sepsis (%) | 4 (6.5) | 7 (2.2) | 0.072 | 0.4 (0.1-1.5) |
URTI (%) | 11 (17.7) | 65 (20.8) | 0.558 | 1.2 (0.6-2.5) |
Reflux (%) | 3 (4.8) | 11 (35.1) | 0.615 | 0.6 (0.2-2.4) |
Pneumonia (%) | 11 (17.2) | 17 (5.4) | 0.001 | 0.2 (0.1-0.6) |
Laboratory findings | ||||
Anemia (%) | 4 (6.5) | 18 (5.8) | 0.830 | 1.0 (0.3-3.0) |
Neutropenia (%) | 4 (6.5) | 9 (2.9) | 0.160 | 0.4 (0.1-1.2) |