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Table 2 Frequency of selected physical findings and clinical events in very young HIV-infected with CD4% < 25% (severe immune suppression) versus CD4 ≥ 25%

From: Utility of clinical parameters to identify HIV infection in infants below ten weeks of age in South Africa: a prospective cohort study

  CD4 < 25% n = 62 CD4 ≥ 25% n = 313 Unadjusted p-value3 AOR (95% CI)3
Female gender (%) 29 (46.8) 187 (59.7) 0.06  
Median age, days (IQR) 52 (42-66) 45 (39-55) 0.0021  
Anthropometry at screening
Median weight, kg (IQR) 4.3 (3.9-5) 4.4 (4.0-4.9) 0.228 1.6 (1.1-2.4)
Weight < 3 rd centile (%) 19 (30.6) 52 (16.6) 0.010 NA
Weight < 15 th centile (%) 36 (56.4) 115 (37.0) 0.004 NA
Weight < 50 th centile (%) 51 (82) 228 (72.8) 0.121 NA
Median length, cm 54 (52.5-55) 54 (52-56) 0.563 1.1 (0.98-1.2)
Median HC, cm 39 (38-40) 39 (38-40) 0.859 1.1 (0.9-1.1)
Physical exam findings at screening
Any LAD # (%) 33 (53.2) 93 (29.7) < 0.001 0.4 (0.2-0.7)
Atopic dermatitis (%) 14 (22.6) 64 (20.4) 0.705 1.1 (0.5-2.1)
Diaper dermatitis 28 (45.2) 111 (35.5) 0.149 0.7 (0.4-1.2)
Oral thrush (%) 29 (46.8) 115 (36.7) 0.138 0.7 (0.4-1.1)
Hepatomegaly (%) 11 (17.7) 19 (6.1) 0.002 0.4 (0.2-0.8)
Splenomegaly (%) 19 (30.6) 51 (16.3) 0.008 0.5 (0.3-0.9)
Clinical event prior to or at screening
Gastroenteritis (%) 12 (19.4) 29 (9.3) 0.020 0.5 (0.2-1.0)
Otitis media (%) 1 (1.6) 5 (1.6) 0.993 1.5 (0.2-13.8)
Sepsis (%) 4 (6.5) 7 (2.2) 0.072 0.4 (0.1-1.5)
URTI (%) 11 (17.7) 65 (20.8) 0.558 1.2 (0.6-2.5)
Reflux (%) 3 (4.8) 11 (35.1) 0.615 0.6 (0.2-2.4)
Pneumonia (%) 11 (17.2) 17 (5.4) 0.001 0.2 (0.1-0.6)
Laboratory findings
Anemia (%) 4 (6.5) 18 (5.8) 0.830 1.0 (0.3-3.0)
Neutropenia (%) 4 (6.5) 9 (2.9) 0.160 0.4 (0.1-1.2)
  1. 1 Kruskal Wallis 2ANOVA 3Fishers exact unless otherwise specified
  2. 3Age-adjusted OR of HIV-infected infants with CD4 ≥ 25% versus those with CD4 < 24%
  3. IQR - Interquartile range. CI - Confidence Interval. HC - Head circumference. URTI - Upper respiratory tract infection.
  4. #Any lymphadenopathy - includes generalized, cervical, axillary or inguinal
  5. *Small sample sizes prevented the calculation of adjusted OR