Table 1 Frequency of selected physical findings and clinical events in very young HIV-infected and exposed uninfected infants.

Female gender (%)

Median age, days (IQR)

57 (46)

48 (38-51)

239 (57)

45 (38-56)

0.18

0.07¹

Anthropometry at screening

Median weight, kg (IQR)

4.8 (4.3-5.2)

4.4 (3.9-4.9)

< 0.001²

0.51 (0.38-0.68)

Weight < 3 ^rd centile (%)

8 (6.4)

79 (18.9)

< 0.001

3.2 (1.4-6.8)

Weight < 15 ^th centile (%)

23 (18.4)

166 (39.8)

< 0.001

2.8 (1.7-4.6)

Weight < 50 ^th centile (%)

79 (63.2)

303 (72.7)

0.04

1.5 (0.98-2.3)

Median length, cm

55 (53-56)

54 (52-56)

0.78²

0.97 (0.91-1.04)

Median HC, cm

39 (38.4-40)

39 (38-40)

0.20²

0.95 (0.88-1.03)

Physical exam findings at screening

Any LAD ^# (%)

6 (5)

132 (32)

< 0.001

8.8 (3.8-20.9)

Candidal rash (%)

8 (6)

46 (11)

0.17

1.6 (0.8-3.6)

Atopic dermatitis (%)

13 (10)

83 (20)

0.01

2.0 (1.1-3.7)

Diaper dermatitis

23 (18)

149 (36)

< 0.001

2.4 (1.5-4.0)

Oral thrush (%)

13 (10)

163 (39)

< 0.001

5.6 (3.0-10.2)

Hepatomegaly (%)

1 (1)

70 (17)

< 0.001

23.5 (3.2-170.8)

Splenomegaly (%)

0 (0)

30 (7)

< 0.001

*

Clinical event prior to or at screening

Gastroenteritis (%)

8 (6)

44 (11)

0.17

1.7 (0.8-3.7)

Otitis media (%)

4 (3)

6 (1)

0.20

0.4 (0.1-1.5)

Sepsis (%)

3 (2)

12 (3)

1.00

1.0 (0.3-3.7)

URTI (%)

24 (19)

81 (19)

1.00

1.0 (0.6-1.7)

Reflux (%)

0 (0)

15 (4)

0.03

*

Pneumonia (%)

7 (6)

29 (7)

0.67

1.2 (0.5-2.8)

Laboratory findings

Anemia (%)

0 (0)

22 (5)

0.004

*

Neutropenia (%)

0 (0)

15 (4)

0.03

*